| Gene Symbol |
Tp53
|
| Entrez Gene |
24842
|
| Alt Symbol |
Trp53, p53
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
tumor protein p53
|
| Other Description |
cellular tumor antigen p53|transformation related protein 53|tumor protein p53 (Li-Fraumeni syndrome)|tumor suppressor p53
|
| Swissprots |
Q4KMA9 O09168 Q66HM0 P10361
|
| Accessions |
AAA41788 AAF43277 AAF43278 AAG34052 AAG34053 EDM04871 EDM04872 EDM04873 P10361 AF209191 AAG35765 AY009504 AAG35178 BC081788 AAH81788 BC098663 AAH98663 CV126174 FQ232659 U90328 AAB80959 X13058 CAA31457 XM_006246594 XP_006246656 XM_006246595 XP_006246657 XM_008767773 XP_008765995 NM_030989 NP_112251
|
| Function |
Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. In cooperation with mitochondrial PPIF is involved in activating oxidative stress-induced necrosis; the function is largely independent of transcription. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. Induces the transcription of long intergenic non-coding RNA p21 (lincRNA-p21) and lincRNA- Mkln1. LincRNA-p21 participates in TP53-dependent transcriptional repression leading to apoptosis and seem to have to e
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Mitochondrion matrix {ECO:0000269|PubMed:22726440}. Note=Interaction with BANP promotes nuclear localization. Translocates to mitochondria upon oxidative stress (By similarity). {ECO:0000250}.
|
| Top Pathways |
Measles, Epstein-Barr virus infection, Sphingolipid signaling pathway, Apoptosis, Central carbon metabolism in cancer
|