Gene Symbol | BEST3 |
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Entrez Gene | 144453 |
Alt Symbol | VMD2L3 |
Species | Human |
Gene Type | protein-coding |
Description | bestrophin 3 |
Other Description | bestrophin-3|vitelliform macular dystrophy 2-like 3|vitelliform macular dystrophy 2-like protein 3 |
Swissprots | Q8N356 Q53YQ7 B5MDI8 Q9BR80 F8VVZ2 Q8N1M1 Q8NFT9 |
Accessions | EAW97232 EAW97233 EAW97234 EAW97235 Q8N1M1 AF440758 AAM76997 AK096459 BAC04797 AY515706 AAR99656 BC006440 AAH06440 BC028087 BC151138 BC166663 AAI66663 BF739974 BP225850 BX374313 DA767581 XM_005268674 XP_005268731 XM_006719252 XP_006719315 XM_006719256 XP_006719319 XM_011537961 XP_011536263 XM_011537962 XP_011536264 XM_011537963 XP_011536265 XM_011537964 XP_011536266 XM_011537965 XP_011536267 NM_001282613 NP_001269542 NM_001282614 NP_001269543 NM_001282615 NP_001269544 NM_001282616 NP_001269545 NM_032735 NP_116124 NM_152439 NP_689652 NR_104220 |
Function | Forms calcium-sensitive chloride channels. Permeable to bicarbonate. {ECO:0000269|PubMed:12907679}. |
Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Present in skeletal muscle and weakly in brain, spinal cord, bone marrow and retina. {ECO:0000269|PubMed:12032738}. |
Bestrophin-3 CRISPR/Cas9 KO Plasmid (h) - sc-410324 from Santa Cruz Biotechnology
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Bestrophin-3 HDR Plasmid (h) - sc-410324-HDR from Santa Cruz Biotechnology
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Bestrophin-3 Double Nickase Plasmid (h) - sc-410324-NIC from Santa Cruz Biotechnology
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Bestrophin-3 Double Nickase Plasmid (h2) - sc-410324-NIC-2 from Santa Cruz Biotechnology
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Bestrophin-3 CRISPR Activation Plasmid (h) - sc-410324-ACT from Santa Cruz Biotechnology
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Bestrophin-3 CRISPR Activation Plasmid (h2) - sc-410324-ACT-2 from Santa Cruz Biotechnology
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Bestrophin-3 Lentiviral Activation Particles (h) - sc-410324-LAC from Santa Cruz Biotechnology
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Bestrophin-3 Lentiviral Activation Particles (h2) - sc-410324-LAC-2 from Santa Cruz Biotechnology
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Bestrophin-3 siRNA (h) - sc-72641 from Santa Cruz Biotechnology
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Bestrophin-3 shRNA Plasmid (h) - sc-72641-SH from Santa Cruz Biotechnology
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Bestrophin-3 shRNA (h) Lentiviral Particles - sc-72641-V from Santa Cruz Biotechnology
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Bestrophin 3 RNAi - H00144453-R01 from Novus Biologicals
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MISSION® esiRNA - EHU097781 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3950 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3950 from Sigma-Aldrich
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BEST3 siRNA (Human) - CRJ5412 from Cohesion Biosciences
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BEST3 - MBS8225301 from MyBioSource
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shRNA set against Human BEST3 (NM_152439.2) - SHH246390 from Creative biogene
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shRNA set against Human BEST3(NM_032735.2) - SHG099475 from Creative biogene
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shRNA set against Human BEST3(NM_152439.2) - SHG099493 from Creative biogene
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BEST3 shRNA Plasmid (Human) - CHJ5412 from Cohesion Biosciences
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BEST3 miRNA 3'UTR clone - MiUTR1H-00876 from Creative biogene
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BEST3 miRNA 3'UTR clone - MiUTR1H-00877 from Creative biogene
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