Oprm1

Gene Symbol Oprm1
Entrez Gene 25601
Alt Symbol MORA, Oprm, Oprrm1
Species Rat
Gene Type protein-coding
Description opioid receptor, mu 1
Other Description M-OR-1|MOR-1|MUOR1|mu opioid receptor splice variant rMOR-1S|mu opioid receptor splice variant rMOR-1Z|mu-type opioid receptor|opioid receptor B
Swissprots Q4VWX8 Q64120 Q62846 Q4VWX7 Q4VWM5 Q4VWM7 Q2TV21 P33535 Q64064 Q2TV20
Accessions EDL92831 EDL92832 EDL92833 EDL92834 P33535 AY225402 AAP44725 AY225403 AAP44726 AY309000 AAQ77384 AY309002 AAQ77386 AY309003 AAQ77387 AY309004 AAQ77388 D16349 BAA03852 DQ680043 ABH03502 EU024650 ABW84396 EU024651 ABW84397 EU024652 ABW84398 EU340244 ACA49729 EU340245 ACA49730 EU340246 ACA49731 FJ041289 ACM90347 HQ699463 AET97616 L13069 AAA41630 L20684 AAA41643 L22455 AAA16075 U02083 AAA70049 U35424 AAA79180 XM_008758731 XP_008756953 NM_001038597 NP_001033686 NM_001038599 NP_001033688 NM_001038600 NP_001033689 NM_001038601 NP_001033690 NM_001304733 NP_001291662 NM_001304734 NP_001291663 NM_001304735 NP_001291664 NM_001304736 NP_001291665 NM_001304737 NP_001291666 NM_001304738 NP_001291667 NM_001304740 NP_001291669 NM_013071 NP_037203 NR_027877
Function Receptor for endogenous opioids such as beta-endorphin and endomorphin. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC),
Subcellular Location Cell membrane; Multi-pass membrane protein.
Tissue Specificity Brain. Is expressed in the cerebral cortex, caudate putamen, nucleus accumbens, septal nuclei, thalamus, hippocampus, and habenula. Not detected in cerebellum.
Top Pathways Morphine addiction, Estrogen signaling pathway, Neuroactive ligand-receptor interaction

Anti-Endomorphin 2 antibody - ab10289 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
ab10289, at a dilution of 1/300, staining Endomorphin 2 in rat dorsal horn by Immunohistochemistry (PFA perfusion fixed frozen sections).

mu Opioid R/OPRM1 Antibody - NB100-1620 from Novus Biologicals

Prices $229.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: mu Opioid R/OPMR1 Antibody [NB100-1620] - Staining of Rat DRG.

mu Opioid R/OPRM1 Antibody - NB100-1618 from Novus Biologicals

Prices $229.00
Sizes 50 µl
Host Guinea Pig
Clonality Polyclonal
Western Blot: mu Opioid R/OPMR1 Antibody [NB100-1618] - Analysis of isolated mouse brain striatum and cerebellum for the non-phospho-MOR antibody or the MOR-P2 antibody. The samples from cerebellum demonstrate a lack of IR for both the non-phospho-MOR antibody and MOR-P2 antibody further showing the selectivity of these antibodies. The images are each representative of four independent experiments. Dilution 1:1000.

mu Opioid Receptor (Ser375) Antibody - bs-3724R from Bioss

Prices $299.50
Sizes 100 µl
Host Rabbit
Antigen: Phospho Mu Opioid Receptor (blue line), 0.2ug/100ul; Mu Opioid Receptor(red line), 0.2ug/100ul\\nPrimary: Antiserum, 1:500, 1:1000, 1:2000, 1:4000, 1:8000, 1:16000, 1:32000; \\nSecondary: HRP conjugated Goat Anti-Rabbit IgG(bs-0295G-HRP) at 1: 5000; \\nTMB staining; \\nRead the data in MicroplateReader by 450nm. \\n

mu-Opioid-Receptor-extracellular-Antibody - AG1412 from Abgent, a WuXi AppTec company

Prices $375.00, $475.00, $575.00
Sizes 25 µl, 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat hippocampus lysate: 1. Anti-µ-Opioid Receptor (extracellular) antibody (#AG1412), (1:200). 2. Anti-µ-Opioid Receptor (extracellular) antibody, preincubated with the control peptide antigen.

OPRM1 Antibody (Phospho-Ser375) (OABF01307) - OABF01307 from Aviva Systems Biology

Prices $309.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

mu Opioid Receptor (Ser375) Antibody, Cy3 Conjugated - bs-3724R-Cy3 from Bioss

Prices $399.50
Sizes 100 µl
Host Rabbit

mu Opioid Receptor (Ser375) Antibody, Cy5 Conjugated - bs-3724R-Cy5 from Bioss

Prices $399.50
Sizes 100 µl
Host Rabbit

mu Opioid Receptor (Ser375) Antibody, Cy5.5 Conjugated - bs-3724R-Cy5.5 from Bioss

Prices $399.50
Sizes 100 µl
Host Rabbit

mu Opioid Receptor (Ser375) Antibody, Cy7 Conjugated - bs-3724R-Cy7 from Bioss

Prices $399.50
Sizes 100 µl
Host Rabbit

mu Opioid Receptor (Ser375) Antibody, FITC Conjugated - bs-3724R-FITC from Bioss

Prices $399.50
Sizes 100 µl
Host Rabbit

mu Opioid Receptor (Ser375) Antibody, Biotin Conjugated - bs-3724R-Biotin from Bioss

Prices $379.50
Sizes 100 µl
Host Rabbit

mu Opioid Receptor (Ser375) Antibody, HRP Conjugated - bs-3724R-HRP from Bioss

Prices $399.50
Sizes 100 µl
Host Rabbit

Guinea pig anti-Rat Mu Opioid Receptor Polyclonal antibody - DPAB2757GR from Creative Diagnostics

Host Guinea Pig
Clonality Polyclonal

mu-Opioid Receptor (extracellular) Antibody - WGA1032 from WuXi Biosciences

Prices $275.00, $375.00, $475.00
Sizes 25 µl, 50 µl, 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat hippocampus lysate: 1. Anti- µ-Opioid Receptor (extracellular) antibody (#WGA1032), (1:200). 2. Anti- µ-Opioid Receptor (extracellular) antibody, preincubated with the control peptide antigen.

Rabbit-Anti-mu-Opioid-Receptor-Ser375-Polyclonal-Antibody - AP52191 from Abgent, a WuXi AppTec company

Prices $265.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

mu Opioid Receptor, Polyclonal Antibody - MBS9216783 from MyBioSource

Prices $340.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

OPRM1 antibody - TA328920 from Acris Antibodies

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis of rat hippocampus lysate: 1. Anti-µ-Opioid Receptor (extracellular) antibody , (1:200). 2. Anti-µ-Opioid Receptor (extracellular) antibody, preincubated with the control peptide antigen.
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