| Gene Symbol | Oprm1 |
|---|---|
| Entrez Gene | 25601 |
| Alt Symbol | MORA, Oprm, Oprrm1 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | opioid receptor, mu 1 |
| Other Description | M-OR-1|MOR-1|MUOR1|mu opioid receptor splice variant rMOR-1S|mu opioid receptor splice variant rMOR-1Z|mu-type opioid receptor|opioid receptor B |
| Swissprots | Q4VWX8 Q64120 Q62846 Q4VWX7 Q4VWM5 Q4VWM7 Q2TV21 P33535 Q64064 Q2TV20 |
| Accessions | EDL92831 EDL92832 EDL92833 EDL92834 P33535 AY225402 AAP44725 AY225403 AAP44726 AY309000 AAQ77384 AY309002 AAQ77386 AY309003 AAQ77387 AY309004 AAQ77388 D16349 BAA03852 DQ680043 ABH03502 EU024650 ABW84396 EU024651 ABW84397 EU024652 ABW84398 EU340244 ACA49729 EU340245 ACA49730 EU340246 ACA49731 FJ041289 ACM90347 HQ699463 AET97616 L13069 AAA41630 L20684 AAA41643 L22455 AAA16075 U02083 AAA70049 U35424 AAA79180 XM_008758731 XP_008756953 NM_001038597 NP_001033686 NM_001038599 NP_001033688 NM_001038600 NP_001033689 NM_001038601 NP_001033690 NM_001304733 NP_001291662 NM_001304734 NP_001291663 NM_001304735 NP_001291664 NM_001304736 NP_001291665 NM_001304737 NP_001291666 NM_001304738 NP_001291667 NM_001304740 NP_001291669 NM_013071 NP_037203 NR_027877 |
| Function | Receptor for endogenous opioids such as beta-endorphin and endomorphin. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell type-specific activity is predominantly coupled to pertussis toxin-sensitive G(i) and G(o) G alpha proteins, GNAI1, GNAI2, GNAI3 and GNAO1 isoforms Alpha-1 and Alpha-2, and to a lesser extend to pertussis toxin-insensitive G alpha proteins GNAZ and GNA15. They mediate an array of downstream cellular responses, including inhibition of adenylate cyclase activity and both N-type and L-type calcium channels, activation of inward rectifying potassium channels, mitogen-activated protein kinase (MAPK), phospholipase C (PLC), phosphoinositide/protein kinase (PKC), |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
| Tissue Specificity | Brain. Is expressed in the cerebral cortex, caudate putamen, nucleus accumbens, septal nuclei, thalamus, hippocampus, and habenula. Not detected in cerebellum. |
| Top Pathways | Morphine addiction, Estrogen signaling pathway, Neuroactive ligand-receptor interaction |