H2AFX

Gene Symbol H2AFX
Entrez Gene 3014
Alt Symbol H2A.X, H2A/X, H2AX
Species Human
Gene Type protein-coding
Description H2A histone family, member X
Other Description H2AX histone|histone H2A.x|histone H2AX
Swissprots Q6IAS5 P16104 Q4ZGJ7
Accessions AAY22178 EAW67451 P16104 BC004915 AAH04915 BC011694 AAH11694 BC013416 AAH13416 CR457079 CAG33360 X14850 CAA32968 NM_002105 NP_002096
Function Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. {ECO:0000269|PubMed:10959836, ECO:0000269|PubMed:12419185, ECO:0000269|PubMed:12607005, ECO:0000269|PubMed:15201865}.
Subcellular Location Nucleus. Chromosome.
Top Pathways Systemic lupus erythematosus, Alcoholism

Histone H2A.X CRISPR/Cas9 KO Plasmid (h) - sc-400538 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.X HDR Plasmid (h) - sc-400538-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.X Double Nickase Plasmid (h) - sc-400538-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.X Double Nickase Plasmid (h2) - sc-400538-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.X CRISPR Activation Plasmid (h) - sc-400538-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.X CRISPR Activation Plasmid (h2) - sc-400538-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.X Lentiviral Activation Particles (h) - sc-400538-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.X Lentiviral Activation Particles (h2) - sc-400538-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Histone H2A.X siRNA (h) - sc-62464 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Histone H2A.X shRNA Plasmid (h) - sc-62464-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Histone H2A.X shRNA (h) Lentiviral Particles - sc-62464-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN1263 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1263 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

H2AFX siRNA (Human) - CRH2048 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

H2AX RNAi - H00003014-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

H2AFX - MBS8200683 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human H2AFX (NM_002105.2) - SHH309838 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human H2AFX(NM_002105.2) - SHH112205 from Creative biogene

Category siRNA
Species Reactivities Human

Human H2AFX siRNA - orb262550 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

H2AFX shRNA Plasmid (Human) - CHH2048 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

H2AFX miRNA 3'UTR clone - MiUTR1H-04355 from Creative biogene

Species Reactivities Human
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