H2AFX

Gene Symbol	H2AFX
Entrez Gene	3014
Alt Symbol	H2A.X, H2A/X, H2AX
Species	Human
Gene Type	protein-coding
Description	H2A histone family, member X
Other Description	H2AX histone\|histone H2A.x\|histone H2AX
Swissprots	Q6IAS5 P16104 Q4ZGJ7
Accessions	AAY22178 EAW67451 P16104 BC004915 AAH04915 BC011694 AAH11694 BC013416 AAH13416 CR457079 CAG33360 X14850 CAA32968 NM_002105 NP_002096
Function	Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C- terminal phosphorylation. {ECO:0000269\|PubMed:10959836, ECO:0000269\|PubMed:12419185, ECO:0000269\|PubMed:12607005, ECO:0000269\|PubMed:15201865}.
Subcellular Location	Nucleus. Chromosome.
Top Pathways	Systemic lupus erythematosus, Alcoholism

Category	Cell Line
Species	Human

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