Gene Symbol | CCL3 |
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Entrez Gene | 6348 |
Alt Symbol | G0S19-1, LD78ALPHA, MIP-1-alpha, MIP1A, SCYA3 |
Species | Human |
Gene Type | protein-coding |
Description | chemokine (C-C motif) ligand 3 |
Other Description | C-C motif chemokine 3|G0/G1 switch regulatory protein 19-1|PAT 464.1|SIS-beta|macrophage inflammatory protein 1-alpha|small inducible cytokine A3 (homologous to mouse Mip-1a)|tonsillar lymphocyte LD78 alpha protein |
Swissprots | P10147 |
Accessions | AAA35858 AAB47170 ABK41952 BAA14172 CAA27643 EAW80100 P10147 AF043339 AAC03539 BC071834 AAH71834 BC171831 AAI71831 BC171891 AAI71891 BX103455 D00044 BAA00029 D63785 BAA09855 M23452 AAA36316 M25315 AAA57255 X03754 CAA27388 NM_002983 NP_002974 |
Function | Monokine with inflammatory and chemokinetic properties. Binds to CCR1, CCR4 and CCR5. One of the major HIV-suppressive factors produced by CD8+ T-cells. Recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, and simian immunodeficiency virus (SIV). {ECO:0000269|PubMed:8525373}. |
Subcellular Location | Secreted. |
Top Pathways | Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway, Chemokine signaling pathway, Chagas disease (American trypanosomiasis), Rheumatoid arthritis |
Active human MIP 1 alpha full length protein - ab192133 from Abcam
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Active Macrophage Inflammatory Protein 1 alpha / CCL3 full length protein - ab9674 from Abcam
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Active Macrophage Inflammatory Protein 1 alpha / CCL3 full length protein - ab9928 from Abcam
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Active mouse MIP 1 alpha full length protein - ab194025 from Abcam
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Active rat Macrophage Inflammatory Protein 1 alpha / CCL3 full length protein - ab9782 from Abcam
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Human Macrophage Inflammatory Protein 1 alpha / CCL3 full length protein - ab106871 from Abcam
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Human Macrophage Inflammatory Protein 1 alpha / CCL3 full length protein - ab175158 from Abcam
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Human Macrophage Inflammatory Protein 1 alpha / CCL3 full length protein - ab176081 from Abcam
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Human Macrophage Inflammatory Protein 1 alpha / CCL3 full length protein - ab83683 from Abcam
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Human Macrophage Inflammatory Protein 1 alpha / CCL3 protein fragment - ab53337 from Abcam
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Macrophage Inflammatory Protein 1 alpha / CCL3 full length protein - ab87629 from Abcam
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Mouse Macrophage Inflammatory Protein 1 alpha / CCL3 full length protein - ab134632 from Abcam
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CCL3 + CC3L1 Antibody Blocking Peptide - LS-E25829 from LifeSpan Bioscience
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CCL3 / MIP-1-Alpha Antibody Blocking Peptide - LS-E9622 from LifeSpan Bioscience
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Recombinant Human CCL3/MIP-1 alpha Protein - NBP2-35011 from Novus Biologicals
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Macrophage Inflammatory Protein 1 alpha Partial Recombinant Protein - H00006348-Q01 from Novus Biologicals
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Macrophage Inflammatory Protein 1 alpha Recombinant Protein - H00006348-P01 from Novus Biologicals
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Macrophage Inflammatory Protein 1 alpha Recombinant Protein - P3651 from Novus Biologicals
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Recombinant Human Macrophage Inflammatory Protein 1 alpha Protein - NBP1-99864 from Novus Biologicals
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Recombinant Human Macrophage Inflammatory Protein 1 alpha Protein - NBP1-51086 from Novus Biologicals
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CCL3/MIP-1 alpha Protein - NBP2-26527 from Novus Biologicals
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CCL3-Antibody-C-term-Blocking-Peptide - BP8527b from Abgent, a WuXi AppTec company
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MIP1 alpha protein - GTX29928 from GeneTex
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MIP1 alpha protein - GTX29674 from GeneTex
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MIP1 alpha protein - GTX29782 from GeneTex
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