FZD4

Gene Symbol	FZD4
Entrez Gene	8322
Alt Symbol	CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4
Species	Human
Gene Type	protein-coding
Description	frizzled class receptor 4
Other Description	WNT receptor frizzled-4|frizzled 4, seven transmembrane spanning receptor|frizzled family receptor 4|frizzled homolog 4|frizzled-4
Swissprots	Q9ULV1 Q6S9E4 Q14C97 A8K9Q3
Accessions	BAB89326 EAW75147 Q9ULV1 AB032417 BAA86286 AB054881 BAB40811 AK025516 AK025791 AK292768 BAF85457 AY462097 AAR23924 BC025750 BC114527 AAI14528 BC114622 AAI14623 NM_012193 NP_036325
Function	Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be
Subcellular Location	Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity	Almost ubiquitous. Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney. Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver.
Top Pathways	Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Frizzled 4 full length protein - ab152853 from Abcam Category Protein Source Wheat germ Species Human

Human Frizzled 4 protein fragment - ab152854 from Abcam Category Protein Source Wheat germ Species Human

Human Frizzled 4 protein fragment - ab198662 from Abcam Category Protein Source HEK 293 cells Species Human

FZD4 / Frizzled 4 Antibody Blocking Peptide - LS-E29010 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD4 / Frizzled 4 Antibody Blocking Peptide - LS-E28978 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

FZD4 / Frizzled 4 Antibody Blocking Peptide - LS-E26628 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FZD4 / Frizzled 4 Antibody Blocking Peptide - LS-E10147 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

FZD4 / Frizzled 4 Antibody Blocking Peptide - LS-E15169 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Frizzled-4 Protein - H00008322-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Frizzled-4 Protein - H00008322-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Frizzled-4 Recombinant Protein - H00008322-G01 from Novus Biologicals Category Protein Prices $579.00 Sizes 10 µg Species Human

FZD4-Antibody-C-term-Blocking-Peptide - BP9471b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Frizzled 4 blocking peptide - GTX88836-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Rat

Recombinant Human Frizzled-4, CF - 5847-FZ-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Recombinant Mouse Frizzled-4 Fc Chimera, CF - 194-FZ-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

Human CD344 (Fc Tag) protein - orb179700 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Cells Species Human

Human Frizzled-4 (His Tag) protein - orb232431 from Biorbyt Category Protein Prices $400.00, $816.00 Sizes 50 μg, 200 μg Species Human

FZD4 Blocking Peptide - 33R-3346 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Frizzled 4 Peptide - AC21-1464-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CD344 / FZD4 / Frizzled-4 - H00008322-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

CD344 / FZD4 / Frizzled-4 - H00008322-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

CD344 / FZD4 / Frizzled-4 - H00008322-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

CD344 / FZD4 / Frizzled-4 - H00008322-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD344 / FZD4 / Frizzled-4 - H00008322-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Frizzled 4 Peptide - 46-660P from ProSci Category Peptide Species Human

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