FZD4

Gene Symbol FZD4
Entrez Gene 8322
Alt Symbol CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4
Species Human
Gene Type protein-coding
Description frizzled class receptor 4
Other Description WNT receptor frizzled-4|frizzled 4, seven transmembrane spanning receptor|frizzled family receptor 4|frizzled homolog 4|frizzled-4
Swissprots Q9ULV1 Q6S9E4 Q14C97 A8K9Q3
Accessions BAB89326 EAW75147 Q9ULV1 AB032417 BAA86286 AB054881 BAB40811 AK025516 AK025791 AK292768 BAF85457 AY462097 AAR23924 BC025750 BC114527 AAI14528 BC114622 AAI14623 NM_012193 NP_036325
Function Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be
Subcellular Location Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Tissue Specificity Almost ubiquitous. Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney. Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver.
Top Pathways Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway

frizzled-4 (C-18) - sc-66450 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
frizzled-4 (C-18): sc-66450. Western blot analysis of frizzled-4 expression in rat skeletal muscle (A) and mouse heart (B) tissue extracts.

frizzled-4 (F-20) - sc-66451 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
frizzled-4 (F-20): sc-66451. Western blot analysis of frizzled-4 expression in 293T whole cell lysate.

frizzled-4 (H-120) - sc-135108 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
frizzled-4 (H-120): sc-135108. Western blot analysis of frizzled-4 expression in Sol8 (A), ES-2 (B), MIA PaCa-2 (C) and 293T (D) whole cell lysates.

frizzled-4 (P-20) - sc-66453 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Frizzled 4 antibody - ab129713 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Frizzled 4 antibody (ab129713) at 1 µg/mlLane 1 : Ovary (Human) Tissue Lysate - adult normal tissueLane 2 : Kidney (Human) Tissue Lysate - adult normal tissueLane 3 : Pancreas (Human) Tissue Lysate - adult normal tissueLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) (ab97051) at 1/10000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-FZD4 / Frizzled 4 Antibody (C-Terminus) IHC-plus™ - LS-A4911 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FZD4 / Frizzled 4 antibody IHC of human Pancreas, Carcinoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-FZD4 / Frizzled 4 Antibody (N-Terminus) IHC-plus™ - LS-A4577 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-FZD4 / Frizzled 4 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-FZD4 / Frizzled 4 Antibody (Extracellular Domain) - LS-C6904 from LifeSpan Bioscience

Prices $345.00
Sizes 50 µg
Host Rat
Clonality Monoclonal

Anti-FZD4 / Frizzled 4 Antibody (Biotin) - LS-C6905 from LifeSpan Bioscience

Prices $345.00
Sizes 50 µg
Host Rat
Clonality Monoclonal

Anti-FZD4 / Frizzled 4 Antibody (Biotin) - LS-C6906 from LifeSpan Bioscience

Prices $650.00
Sizes 50 µg
Host Goat
Clonality Polyclonal

Anti-FZD4 / Frizzled 4 Antibody - LS-C6907 from LifeSpan Bioscience

Prices $605.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-FZD4 / Frizzled 4 Antibody (aa131-180) - LS-C120596 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of A549 cells, using FZD4 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-FZD4 / Frizzled 4 Antibody (aa39-51) - LS-C61739 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (1 ug/ml) staining of Small Intestine (Ileum) cell lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-FZD4 / Frizzled 4 Antibody (aa131-180) - LS-C120660 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunofluorescence of LOVO cells, using FZD4 Antibody. The picture on the right is treated with the synthesized peptide.

Anti-FZD4 / Frizzled 4 Antibody - LS-C150199 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Frizzled-4 in Embryonic Mouse Neuronal Tissue. Frizzled-4 was detected in immersion fixed frozen sections of embryonic mouse neuronal tissue (E11) using 15 ug/ml Goat Anti-Mouse Frizzled-4 Antigen Affinity-purified Polyclonal Antibody overnight at 4°C. Tissue was stained with Anti-Goat HRP-DAB (brown) and counterstained with hematoxylin (blue). Specific labeling was localized to the plasma membrane and cytoplasm of neuronal cells in the midbrain.

Anti-FZD4 / Frizzled 4 Antibody (aa495-522, AP) - LS-C214417 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD4 / Frizzled 4 Antibody (aa495-522, APC) - LS-C214418 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD4 / Frizzled 4 Antibody (aa495-522, Biotin) - LS-C214419 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD4 / Frizzled 4 Antibody (aa495-522, FITC) - LS-C214420 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD4 / Frizzled 4 Antibody (aa495-522, Azide-free, HRP) - LS-C214421 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD4 / Frizzled 4 Antibody (aa280-329) - LS-C201393 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of Human COLO205. GPCR antibody dilution 1.0 ug/ml.

Anti-FZD4 / Frizzled 4 Antibody (aa495-522, PE) - LS-C214423 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD4 / Frizzled 4 Antibody (aa501-531) - LS-C321498 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-FZD4 / Frizzled 4 Antibody (clone 3G7) - LS-C198548 from LifeSpan Bioscience

Prices $355.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 3G7
Western Blot analysis of FZD4 expression in transfected 293T cell line by FZD4 monoclonal antibody (M02), clone 3G7.Lane 1: FZD4 transfected lysate (Predicted MW: 59.9 KDa).Lane 2: Non-transfected lysate.

Anti-FZD4 / Frizzled 4 Antibody (aa495-522) - LS-C166296 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Western blot of FZD4 Antibody in mouse heart tissue lysates (35 ug/lane). FZD4 (arrow) was detected using the purified antibody.
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