| Gene Symbol |
FZD4
|
| Entrez Gene |
8322
|
| Alt Symbol |
CD344, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
frizzled class receptor 4
|
| Other Description |
WNT receptor frizzled-4|frizzled 4, seven transmembrane spanning receptor|frizzled family receptor 4|frizzled homolog 4|frizzled-4
|
| Swissprots |
Q9ULV1 Q6S9E4 Q14C97 A8K9Q3
|
| Accessions |
BAB89326 EAW75147 Q9ULV1 AB032417 BAA86286 AB054881 BAB40811 AK025516 AK025791 AK292768 BAF85457 AY462097 AAR23924 BC025750 BC114527 AAI14528 BC114622 AAI14623 NM_012193 NP_036325
|
| Function |
Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin (CTNNB1) canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin (CTNNB1) and activation of Wnt target genes. Plays a critical role in retinal vascularization by acting as a receptor for Wnt proteins and norrin (NDP). In retina, it can be both activated by Wnt protein-binding, but also by a Wnt-independent signaling via binding of norrin (NDP), promoting in both cases beta-catenin (CTNNB1) accumulation and stimulation of LEF/TCF-mediated transcriptional programs. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be
|
| Subcellular Location |
Membrane; Multi-pass membrane protein. Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Almost ubiquitous. Largely expressed in adult heart, skeletal muscle, ovary, and fetal kidney. Moderate amounts in adult liver, kidney, pancreas, spleen, and fetal lung, and small amounts in placenta, adult lung, prostate, testis, colon, fetal brain and liver.
|
| Top Pathways |
Wnt signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection, Hippo signaling pathway
|