ILK

Gene Symbol ILK
Entrez Gene 3611
Alt Symbol HEL-S-28, ILK-1, ILK-2, P59, p59ILK
Species Human
Gene Type protein-coding
Description integrin-linked kinase
Other Description 59 kDa serine/threonine-protein kinase|epididymis secretory protein Li 28|integrin-linked kinase-2|integrin-linked protein kinase
Swissprots Q68DZ3 D3DQU0 B7Z418 B7Z1I0 Q13418 P57043
Accessions AAF74449 CAB99253 EAW68688 EAW68689 EAW68690 Q13418 AB209416 BAD92653 AK293474 BAH11516 AK296628 BAH12404 AK314843 BC001554 AAH01554 CB113885 CR407673 CAG28601 CR749220 CAH18077 DC379936 DC380243 DQ891172 ABM82098 DQ894355 ABM85281 EU794625 ACJ13679 HY257434 U40282 AAC16892 XM_005252904 XP_005252961 XM_005252905 XP_005252962 XM_011520065 XP_011518367 NM_001014794 NP_001014794 NM_001014795 NP_001014795 NM_001278441 NP_001265370 NM_001278442 NP_001265371 NM_004517 NP_004508
Function Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Subcellular Location Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, myofibril, sarcomere.
Tissue Specificity Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
Top Pathways Focal adhesion, Endometrial cancer, PPAR signaling pathway, Bacterial invasion of epithelial cells

SignalSilence ® ILK1 siRNA II - 6528 from Cell Signaling Technology

Category siRNA
Prices $249.00
Sizes 300 µl (3 nmol)
Western blot analysis of extracts from HeLa cells, transfected with 100 nM SignalSilence ® Control siRNA (Fluorescein Conjugate) #6201 (-) or SignalSilence ® ILK1 siRNA I #6202 or SignalSilence ® ILK1 siRNA II (+), using ILK1 (4G9) Rabbit mAb #3856 and β-Actin Antibody #4967. ILK1 (4G9) Rabbit mAb confirms silencing of ILK1 expression and β-Actin Antibody is used to control for loading and specificity of ILK1 siRNA.

SignalSilence ® ILK1 siRNA I - 6202 from Cell Signaling Technology

Category siRNA
Prices $256.00
Sizes 300 µl (3 nmol)
Species Reactivities Human
Western blot analysis of extracts from HeLa cells, transfected with 50 nM non-targeted siRNA (-) or 100 nM SignalSilence ® ILK1 siRNA I (+), using ILK1 Antibody #3862 and Cofilin Antibody #3312. The ILK1 antibody confirms silencing of ILK1 expression and the cofilin antibody controls for protein loading and specificity of ILK1 siRNA.

ILK CRISPR/Cas9 KO Plasmid (h) - sc-400864 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILK HDR Plasmid (h) - sc-400864-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILK Double Nickase Plasmid (h) - sc-400864-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILK Double Nickase Plasmid (h2) - sc-400864-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILK CRISPR Activation Plasmid (h) - sc-400864-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILK CRISPR Activation Plasmid (h2) - sc-400864-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILK Lentiviral Activation Particles (h) - sc-400864-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILK Lentiviral Activation Particles (h2) - sc-400864-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ILK siRNA (h) - sc-35666 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ILK shRNA Plasmid (h) - sc-35666-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ILK shRNA (h) Lentiviral Particles - sc-35666-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ILK RNAi - H00003611-R01V from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human
Western Blot: ILK RNAi [H00003611-R01V] - Analysis of ILK over-expressed 293 cell line, cotransfected with ILK Validated Chimera RNAi or non-transfected control. Blot probed with H00003611-M01. GAPDH (36.1 kDa) used as loading control.

ILK RNAi - H00003611-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

ILK RNAi - H00003611-R06 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

ILK RNAi - H00003611-R04 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU143271 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0963 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0961 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

MISSION® siRNA - SIHK0962 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1358 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1358 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR01423 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr01423

ILK siRNA (Human) - CRH2417 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human
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