ILK

Gene Symbol	ILK
Entrez Gene	3611
Alt Symbol	HEL-S-28, ILK-1, ILK-2, P59, p59ILK
Species	Human
Gene Type	protein-coding
Description	integrin-linked kinase
Other Description	59 kDa serine/threonine-protein kinase|epididymis secretory protein Li 28|integrin-linked kinase-2|integrin-linked protein kinase
Swissprots	Q68DZ3 D3DQU0 B7Z418 B7Z1I0 Q13418 P57043
Accessions	AAF74449 CAB99253 EAW68688 EAW68689 EAW68690 Q13418 AB209416 BAD92653 AK293474 BAH11516 AK296628 BAH12404 AK314843 BC001554 AAH01554 CB113885 CR407673 CAG28601 CR749220 CAH18077 DC379936 DC380243 DQ891172 ABM82098 DQ894355 ABM85281 EU794625 ACJ13679 HY257434 U40282 AAC16892 XM_005252904 XP_005252961 XM_005252905 XP_005252962 XM_011520065 XP_011518367 NM_001014794 NP_001014794 NM_001014795 NP_001014795 NM_001278441 NP_001265370 NM_001278442 NP_001265371 NM_004517 NP_004508
Function	Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Subcellular Location	Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, myofibril, sarcomere.
Tissue Specificity	Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
Top Pathways	Focal adhesion, Endometrial cancer, PPAR signaling pathway, Bacterial invasion of epithelial cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ILK-Over-expression-Lysate - LY10421a from Abgent, a WuXi AppTec company Category Cell Lysate Prices $325.00 Sizes 100 µg

ILK HEK293 Cell Transient Overexpression Lysate (Non-Denatured) - L134T6 from Acris Antibodies Category Cell Lysate Prices $290.00 Sizes 100 µg

ILK 293 Cell Lysate - 409857 from ABBIOTEC Category Cell Lysate Prices $672.00 Sizes 100 µg

ILK 293 Cell Lysate - 401309 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

ILK Overexpression Lysate (Native) - NBL1-11974 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ILK Overexpression Lysate (Native) - NBL1-11975 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

ILK (h): 293T Lysate - sc-113563 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

ILK (h3): 293T Lysate - sc-170660 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

ILK (h4): 293T Lysate - sc-158634 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

ILK Over-expression Lysate Product - GWB-9ECE57 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

ILK Over-expression Lysate Product - GWB-54E227 from Genway Biotech Category Cell Lysate Prices $756.00 Sizes 100 µg Species Human

ILK-knockout Cell lysate - LC810117 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human ILK Knockdown Stable Cell Line - CSC-DC007622 from Creative biogene Category Cell Line Species Human

Human ILK Knockout Cell Line-HeLa - CSC-RT0582 from Creative biogene Category Cell Line Species Human

ILK KO Cell Lysate-HeLa - CLKO-0087 from Creative biogene Category Cell Lysate

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