ILK

Gene Symbol	ILK
Entrez Gene	3611
Alt Symbol	HEL-S-28, ILK-1, ILK-2, P59, p59ILK
Species	Human
Gene Type	protein-coding
Description	integrin-linked kinase
Other Description	59 kDa serine/threonine-protein kinase|epididymis secretory protein Li 28|integrin-linked kinase-2|integrin-linked protein kinase
Swissprots	Q68DZ3 D3DQU0 B7Z418 B7Z1I0 Q13418 P57043
Accessions	AAF74449 CAB99253 EAW68688 EAW68689 EAW68690 Q13418 AB209416 BAD92653 AK293474 BAH11516 AK296628 BAH12404 AK314843 BC001554 AAH01554 CB113885 CR407673 CAG28601 CR749220 CAH18077 DC379936 DC380243 DQ891172 ABM82098 DQ894355 ABM85281 EU794625 ACJ13679 HY257434 U40282 AAC16892 XM_005252904 XP_005252961 XM_005252905 XP_005252962 XM_011520065 XP_011518367 NM_001014794 NP_001014794 NM_001014795 NP_001014795 NM_001278441 NP_001265370 NM_001278442 NP_001265371 NM_004517 NP_004508
Function	Receptor-proximal protein kinase regulating integrin- mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
Subcellular Location	Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium {ECO:0000250}. Cytoplasm, myofibril, sarcomere.
Tissue Specificity	Highly expressed in heart followed by skeletal muscle, pancreas and kidney. Weakly expressed in placenta, lung and liver.
Top Pathways	Focal adhesion, Endometrial cancer, PPAR signaling pathway, Bacterial invasion of epithelial cells

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Integrin linked ILK full length protein - ab83119 from Abcam Category Protein Source E. coli Species Human

Human Integrin linked ILK full length protein - ab82815 from Abcam Category Protein Source E. coli Species Human

Human Integrin linked ILK peptide - ab23275 from Abcam Category Peptide Species Human

Recombinant Human ILK Protein - H00003611-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ILK Protein - H00003611-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ILK Peptide - P1621 from Novus Biologicals Category Peptide Species Human

ILK Peptide - P1647 from Novus Biologicals Category Peptide Species Human

ILK Peptide - P2686 from Novus Biologicals Category Peptide Species Human

ILK Peptide - P2684 from Novus Biologicals Category Peptide Species Human

ILK Peptide - P2683 from Novus Biologicals Category Peptide Species Human

ILK Peptide - P2681 from Novus Biologicals Category Peptide Species Human

ILK Peptide - P2680 from Novus Biologicals Category Peptide Species Human

ILK Peptide - P2194 from Novus Biologicals Category Peptide Species Human

Phospho-ILKS246-Antibody-Blocking-peptide - BP3514a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-ILKT173-Antibody-Blocking-peptide - BP3488a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

Phospho-ILKS343-Antibody-Blocking-peptide - BP3679a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

ILK2-Antibody-A197-site-specific-Blocking-Peptide - BP7077d from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ILK2ILK1-Antibody-C-term-Blocking-Peptide - BP7077b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ILK-Antibody-S343-Blocking-Peptide - BP7651h from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ILK-Antibody-T173-Blocking-Peptide - BP7651f from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ILK-Antibody-S246-Blocking-Peptide - BP7651e from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ILK Protein Lysate (APL11220) - APL11220 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

ILK Protein Lysate (APL11221) - APL11221 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

ILK Protein Lysate (APL11222) - APL11222 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

ILK1 Protein (OPPA01925) - OPPA01925 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Search more