| Gene Symbol | TAF4B |
|---|---|
| Entrez Gene | 6875 |
| Alt Symbol | SPGF13, TAF2C2, TAFII105 |
| Species | Human |
| Gene Type | protein-coding |
| Description | TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa |
| Other Description | TAF(II)105|TATA box binding protein (TBP)-associated factor 4B|TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD|transcription initiation factor TFIID 105 kDa subunit|transcription initiation factor TFIID subunit 4B |
| Swissprots | Q29YA5 Q29YA4 Q92750 |
| Accessions | BAF51562 CCO13829 EAX01217 EAX01218 Q92750 AB234096 BAF51561 AK302593 BAG63845 AY888048 AAX14897 AY888049 AAX14898 BC016360 BC032791 BC169304 BC169305 Y09321 CAA70499 XM_005258339 XP_005258396 XM_006722528 XP_006722591 XM_011526153 XP_011524455 NM_001293725 NP_001280654 NM_005640 NP_005631 NR_121653 |
| Function | Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. {ECO:0000250|UniProtKB:G5E8Z2, ECO:0000269|PubMed:10828057, ECO:0000269|PubMed:10849440, ECO:0000269|PubMed:16088961, ECO:0000303|PubMed:24431330}. |
| Subcellular Location | Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation. |
| Tissue Specificity | Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells. {ECO:0000269|PubMed:16088961, ECO:0000269|PubMed:8858156}. |
| Top Pathways | Huntington's disease, Herpes simplex infection, Basal transcription factors |
TAF II p105 CRISPR/Cas9 KO Plasmid (h) - sc-407734 from Santa Cruz Biotechnology
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TAF II p105 HDR Plasmid (h) - sc-407734-HDR from Santa Cruz Biotechnology
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TAF II p105 Double Nickase Plasmid (h) - sc-407734-NIC from Santa Cruz Biotechnology
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TAF II p105 Double Nickase Plasmid (h2) - sc-407734-NIC-2 from Santa Cruz Biotechnology
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TAF II p105 CRISPR Activation Plasmid (h) - sc-407734-ACT from Santa Cruz Biotechnology
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TAF II p105 CRISPR Activation Plasmid (h2) - sc-407734-ACT-2 from Santa Cruz Biotechnology
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TAF II p105 Lentiviral Activation Particles (h) - sc-407734-LAC from Santa Cruz Biotechnology
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TAF II p105 Lentiviral Activation Particles (h2) - sc-407734-LAC-2 from Santa Cruz Biotechnology
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TAF II p105 siRNA (h) - sc-76625 from Santa Cruz Biotechnology
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TAF II p105 shRNA Plasmid (h) - sc-76625-SH from Santa Cruz Biotechnology
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TAF II p105 shRNA (h) Lentiviral Particles - sc-76625-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU107001 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20973 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20973 from Sigma-Aldrich
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TAF4B siRNA (Human) - CRH4704 from Cohesion Biosciences
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TAF4B - MBS8209153 from MyBioSource
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shRNA set against Human TAF4B (NM_005640.1) - SHH422728 from Creative biogene
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Human TAF4B siRNA - orb265206 from Biorbyt
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TAF4B shRNA Plasmid (Human) - CHH4704 from Cohesion Biosciences
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TAF4B miRNA 3'UTR clone - MiUTR1H-10157 from Creative biogene
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