| Gene Symbol |
TAF4B
|
| Entrez Gene |
6875
|
| Alt Symbol |
SPGF13, TAF2C2, TAFII105
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
TAF4b RNA polymerase II, TATA box binding protein (TBP)-associated factor, 105kDa
|
| Other Description |
TAF(II)105|TATA box binding protein (TBP)-associated factor 4B|TATA box binding protein (TBP)-associated factor, RNA polymerase II, C2, 105kD|transcription initiation factor TFIID 105 kDa subunit|transcription initiation factor TFIID subunit 4B
|
| Swissprots |
Q29YA5 Q29YA4 Q92750
|
| Accessions |
BAF51562 CCO13829 EAX01217 EAX01218 Q92750 AB234096 BAF51561 AK302593 BAG63845 AY888048 AAX14897 AY888049 AAX14898 BC016360 BC032791 BC169304 BC169305 Y09321 CAA70499 XM_005258339 XP_005258396 XM_006722528 XP_006722591 XM_011526153 XP_011524455 NM_001293725 NP_001280654 NM_005640 NP_005631 NR_121653
|
| Function |
Cell type-specific subunit of the general transcription factor TFIID that may function as a gene-selective coactivator in certain cells. TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. TAF4B is a transcriptional coactivator of the p65/RELA NF-kappa-B subunit. Involved in the activation of a subset of antiapoptotic genes including TNFAIP3. May be involved in regulating folliculogenesis. Through interaction with OCBA/POU2AF1, acts as a coactivator of B-cell-specific transcription. Plays a role in spermiogenesis and oogenesis. {ECO:0000250|UniProtKB:G5E8Z2, ECO:0000269|PubMed:10828057, ECO:0000269|PubMed:10849440, ECO:0000269|PubMed:16088961, ECO:0000303|PubMed:24431330}.
|
| Subcellular Location |
Nucleus. Cytoplasm. Note=Export into the cytoplasm is mediated by a CRM1-independent nuclear export pathway and not by phosphorylation.
|
| Tissue Specificity |
Preferentially expressed in ovarian granulosa cells (at protein level). Highly expressed in B-cells. {ECO:0000269|PubMed:16088961, ECO:0000269|PubMed:8858156}.
|
| Top Pathways |
Huntington's disease, Herpes simplex infection, Basal transcription factors
|