| Gene Symbol |
KDSR
|
| Entrez Gene |
2531
|
| Alt Symbol |
DHSR, FVT1, SDR35C1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
3-ketodihydrosphingosine reductase
|
| Other Description |
3-dehydrosphinganine reductase|FVT-1|KDS reductase|follicular lymphoma variant translocation 1|follicular variant translocation protein 1|short chain dehydrogenase/reductase family 35C member 1|short chain dehydrogenase/reductase family 35C, member 1
|
| Swissprots |
B2R5Y1 Q06136 B4DMX0
|
| Accessions |
EAW63140 EAW63141 Q06136 AF086045 AK025120 AK093874 AK126679 AK297670 BAG60032 AK312360 BAG35278 BC008797 AAH08797 BI458411 BT006782 AAP35428 X63657 CAA45197 XM_005266677 XP_005266734 XM_006722433 XP_006722496 NM_002035 NP_002026
|
| Function |
Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:15328338}; Multi-pass membrane protein {ECO:0000269|PubMed:15328338}.
|
| Tissue Specificity |
Expressed in all tissues examined. Highest expression in placenta. High expression in lung, kidney, stomach and small intestine, low expression in heart, spleen and skeletal muscle. Weakly expressed in normal hematopoietic tissues. Higher expression in some T-cell malignancies and PHA-stimulated lymphocytes.
|
| Top Pathways |
Sphingolipid metabolism
|
![Western Blot: FVT1 Overexpression Lysate (Adult Normal) [NBP2-10794] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for FVT1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9503_FVT1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-10794-img0001.jpg)