LCN2

Gene Symbol	LCN2
Entrez Gene	3934
Alt Symbol	24p3, MSFI, NGAL
Species	Human
Gene Type	protein-coding
Description	lipocalin 2
Other Description	25 kDa alpha-2-microglobulin-related subunit of MMP-9|lipocalin-2|migration-stimulating factor inhibitor|neutrophil gelatinase-associated lipocalin|oncogene 24p3|p25|siderocalin LCN2
Swissprots	B4DWV4 Q6FGL5 B7ZAA2 Q92683 Q5SYW0 P30150 P80188 A6NII8 Q5SYV9
Accessions	CAA67574 EAW87748 EAW87749 EAW87750 P80188 AK301694 BAG63166 AK307311 AK316217 BAH14588 AW778875 BC033089 AAH33089 BF354583 BM977724 BP272828 BX644845 CA454137 CR542092 CAG46889 EU644752 ACD02429 N79823 S75256 AAD14168 X83006 CAA58127 NM_005564 NP_005555
Function	Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, i
Subcellular Location	Secreted {ECO:0000269|PubMed:12453413}. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.
Tissue Specificity	Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. {ECO:0000269|PubMed:9339356}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Dog Lipocalin-2 / NGAL full length protein - ab188060 from Abcam Category Protein Prices $533.00 Sizes 1 ml Source E. coli Species Dog

Human Lipocalin 2 full length protein - ab175463 from Abcam Category Protein Source E. coli Species Human

Human Lipocalin 2 full length protein - ab92916 from Abcam Category Protein Source E. coli Species Human

Human Lipocalin 2 full length protein - ab95007 from Abcam Category Protein Source E. coli Species Human

Human Lipocalin 2 full length protein - ab167728 from Abcam Category Protein Source HEK 293 cells Species Human

Human Lipocalin 2 full length protein - ab108565 from Abcam Category Protein Source HEK 293 cells Species Human

Human Lipocalin 2 full length protein - ab53368 from Abcam Category Protein Source E. coli Species Human

Human Lipocalin 2 full length protein - ab194056 from Abcam Category Protein Source HEK 293 cells Species Human

Human Lipocalin 2 peptide - ab41758 from Abcam Category Peptide

Human Lipocalin-2 / NGAL full length protein - ab188461 from Abcam Category Protein Source E. coli Species Human

Lipocalin 2 full length protein - ab188054 from Abcam Category Protein Source E. coli

Lipocalin 2 peptide - ab187960 from Abcam Category Peptide

Lipocalin 2 peptide (60-72) - ab45738 from Abcam Category Peptide Species Human

Mouse Lipocalin 2 full length protein - ab95008 from Abcam Category Protein Source E. coli Species Mouse

Mouse Lipocalin 2 full length protein - ab108588 from Abcam Category Protein Source HEK 293 cells Species Mouse

Mouse Lipocalin 2 full length protein - ab188051 from Abcam Category Protein Source E. coli Species Mouse

Mouse Lipocalin 2 full length protein - ab202251 from Abcam Category Protein Source E. coli Species Mouse

Pig Lipocalin 2 full length protein - ab188050 from Abcam Category Protein Source E. coli Species Pig

Rat Lipocalin 2 full length protein - ab188053 from Abcam Category Protein Source E. coli Species Rat

Rat Lipocalin 2 full length protein - ab108563 from Abcam Category Protein Source HEK 293 cells Species Rat

LCN2 / Lipocalin 2 / NGAL Antibody Blocking Peptide - LS-E25880 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LCN2 / Lipocalin 2 / NGAL Antibody Blocking Peptide - LS-E26575 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Lipocalin-2/NGAL Recombinant Protein - H00003934-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human Lipocalin-2/NGAL Protein - NBP1-99205 from Novus Biologicals Category Protein Prices $165.00 Sizes 10 µg Source E. coli Species Human

Lipocalin-2/NGAL Protein - NBP1-99620 from Novus Biologicals Category Protein Species Human

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