LCN2

Gene Symbol	LCN2
Entrez Gene	3934
Alt Symbol	24p3, MSFI, NGAL
Species	Human
Gene Type	protein-coding
Description	lipocalin 2
Other Description	25 kDa alpha-2-microglobulin-related subunit of MMP-9|lipocalin-2|migration-stimulating factor inhibitor|neutrophil gelatinase-associated lipocalin|oncogene 24p3|p25|siderocalin LCN2
Swissprots	B4DWV4 Q6FGL5 B7ZAA2 Q92683 Q5SYW0 P30150 P80188 A6NII8 Q5SYV9
Accessions	CAA67574 EAW87748 EAW87749 EAW87750 P80188 AK301694 BAG63166 AK307311 AK316217 BAH14588 AW778875 BC033089 AAH33089 BF354583 BM977724 BP272828 BX644845 CA454137 CR542092 CAG46889 EU644752 ACD02429 N79823 S75256 AAD14168 X83006 CAA58127 NM_005564 NP_005555
Function	Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, i
Subcellular Location	Secreted {ECO:0000269|PubMed:12453413}. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.
Tissue Specificity	Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. {ECO:0000269|PubMed:9339356}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Lipocalin 2 (NGAL) Human ELISA Kit - ab113326 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 4 pg/ml Range 4.1 pg/ml - 1000 pg/ml

Lipocalin-2 (NGAL) Human ELISA Kit - ab119600 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 10 pg/ml Range 156 pg/ml - 10000 pg/ml

Lipocalin-2 (NGAL) Rat ELISA Kit - ab119602 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 10 pg/ml Range 156 pg/ml - 10000 pg/ml

Rat LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F2722 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 78 pg/ml Range 4.1-1000 pg/ml

Human LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F2720 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 10 pg/ml Range 4.1-1000 pg/ml

Mouse LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F2721 from LifeSpan Bioscience Category ELISA Kit Prices $570.00 Sizes 1 plate Sensitivity 78 pg/ml Range 4.1-1000 pg/ml

Human LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F4329 from LifeSpan Bioscience Category ELISA Kit Prices $580.00 Sizes 1 plate Sensitivity 0.069 ng/ml Range 4.1-1000 pg/ml

Mouse LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F4586 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 4.1-1000 pg/ml

Rat LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F4585 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.34 ng/ml Range 4.1-1000 pg/ml

Pig LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F5276 from LifeSpan Bioscience Category ELISA Kit Prices $820.00 Sizes 1 plate Sensitivity 0.312 ng/ml Range 4.1-1000 pg/ml

Human LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F456 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 4.1 pg/ml Range 4.1-1000 pg/ml

Rat LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F516 from LifeSpan Bioscience Category ELISA Kit Prices $520.00, $930.00, $2,140.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 32.77 pg/ml Range 4.1-1000 pg/ml

Mouse LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F499 from LifeSpan Bioscience Category ELISA Kit Prices $600.00, $1,100.00, $2,520.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 0.025 ng/ml Range 4.1-1000 pg/ml

Human LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F709 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 4.1-1000 pg/ml

Human LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F10094 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 24.21 pg/ml Range 4.1-1000 pg/ml

Human LCN2 / Lipocalin 2 / NGAL ELISA Kit (Sandwich ELISA) - LS-F12153 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 0.156 Range 4.1-1000 pg/ml

Human NGAL/MMP9 Complex ELISA Kit (Sandwich ELISA) - LS-F10350 from LifeSpan Bioscience Category ELISA Kit Prices $630.00 Sizes 1 plate Sensitivity 0.029 ng/ml Range 0.312-20 ng/ml

Human Lipocalin-2 / NGAL ELISA Kit - RAB0332 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Lipocalin-2/NGAL BioAssay™ ELISA Kit, Mouse - 143953 from USBiological Life Science Category ELISA Kit Sensitivity < 10 pg/ml Range 78pg/ml-5, 000pg/ml

Lipocalin-2/NGAL BioAssay™ ELISA Kit, Rat - 143954 from USBiological Life Science Category ELISA Kit Sensitivity < 10 pg/ml Range 156pg/ml-10,000pg/ml

NGAL/MMP-9 Complex, BioAssay™ ELISA Kit (Human) - 227842 from USBiological Life Science Category ELISA Kit Sensitivity Sensitivity: Range 0.313-20ng/ml

Rat Lipocalin-2/NGAL Luminex Performance Assay - LRK3508 from R&D Systems

Human Lipocalin-2/NGAL Magnetic Luminex Performance Assay - LHK1757 from R&D Systems

Human Lipocalin-2/NGAL Quantikine ELISA Kit - DLCN20 from R&D Systems Category ELISA Kit Prices $479.00, $2,290.00, $15,560.00 Sizes 1 kit, 1 pack (6 Plates), 1 pack (50 Plates) Sensitivity 0.04 ng/mL Range 0.2 - 10 ng/mL (Cell Culture Supernates, Serum, Heparin Plasma, Saliva, Urine)

Human Lipocalin-2/NGAL Quantikine PharmPak (50 Plates) - PDLCN20 from R&D Systems Category ELISA Kit Sensitivity 0.04 ng/mL Range 0.156 - 10 ng/mL (Serum, Heparin Plasma, Saliva, Cell Culture Supernates, Urine)

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