LCN2
| Gene Symbol | LCN2 |
|---|---|
| Entrez Gene | 3934 |
| Alt Symbol | 24p3, MSFI, NGAL |
| Species | Human |
| Gene Type | protein-coding |
| Description | lipocalin 2 |
| Other Description | 25 kDa alpha-2-microglobulin-related subunit of MMP-9|lipocalin-2|migration-stimulating factor inhibitor|neutrophil gelatinase-associated lipocalin|oncogene 24p3|p25|siderocalin LCN2 |
| Swissprots | B4DWV4 Q6FGL5 B7ZAA2 Q92683 Q5SYW0 P30150 P80188 A6NII8 Q5SYV9 |
| Accessions | CAA67574 EAW87748 EAW87749 EAW87750 P80188 AK301694 BAG63166 AK307311 AK316217 BAH14588 AW778875 BC033089 AAH33089 BF354583 BM977724 BP272828 BX644845 CA454137 CR542092 CAG46889 EU644752 ACD02429 N79823 S75256 AAD14168 X83006 CAA58127 NM_005564 NP_005555 |
| Function | Iron-trafficking protein involved in multiple processes such as apoptosis, innate immunity and renal development. Binds iron through association with 2,5-dihydroxybenzoic acid (2,5- DHBA), a siderophore that shares structural similarities with bacterial enterobactin, and delivers or removes iron from the cell, depending on the context. Iron-bound form (holo-24p3) is internalized following binding to the SLC22A17 (24p3R) receptor, leading to release of iron and subsequent increase of intracellular iron concentration. In contrast, association of the iron-free form (apo-24p3) with the SLC22A17 (24p3R) receptor is followed by association with an intracellular siderophore, iron chelation and iron transfer to the extracellular medium, thereby reducing intracellular iron concentration. Involved in apoptosis due to interleukin-3 (IL3) deprivation: iron-loaded form increases intracellular iron concentration without promoting apoptosis, while iron-free form decreases intracellular iron levels, i |
| Subcellular Location | Secreted {ECO:0000269|PubMed:12453413}. Note=Upon binding to the SLC22A17 (24p3R) receptor, it is internalized. |
| Tissue Specificity | Expressed in bone marrow and in tissues that are prone to exposure to microorganism. High expression is found in bone marrow as well as in uterus, prostate, salivary gland, stomach, appendix, colon, trachea and lung. Not found in the small intestine or peripheral blood leukocytes. {ECO:0000269|PubMed:9339356}. |
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