Gene Symbol | TNFRSF18 |
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Entrez Gene | 8784 |
Alt Symbol | AITR, CD357, GITR, GITR-D |
Species | Human |
Gene Type | protein-coding |
Description | tumor necrosis factor receptor superfamily, member 18 |
Other Description | TNF receptor superfamily activation-inducible protein|activation-inducible TNFR family receptor|glucocorticoid-induced TNFR-related protein|tumor necrosis factor receptor superfamily member 18 |
Swissprots | B1AME1 Q9NYJ9 Q5U0I4 O95851 Q9Y5U5 |
Accessions | EAW56282 EAW56283 EAW56284 Q9Y5U5 AF117297 AAD19694 AF125304 AAD22635 AF241229 AAF63506 AY358877 AAQ89236 BC152381 AAI52382 BC152386 AAI52387 BC156102 AAI56103 BC156964 AAI56965 BE244247 BT019531 AAV38338 BT019532 AAV38339 NM_004195 NP_004186 NM_148901 NP_683699 NM_148902 NP_683700 |
Function | Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway. |
Subcellular Location | Isoform 1: Cell membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed in lymph node, peripheral blood leukocytes and weakly in spleen. |
Top Pathways | Cytokine-cytokine receptor interaction |
GITR CRISPR/Cas9 KO Plasmid (h) - sc-404899 from Santa Cruz Biotechnology
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GITR HDR Plasmid (h) - sc-404899-HDR from Santa Cruz Biotechnology
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GITR Double Nickase Plasmid (h) - sc-404899-NIC from Santa Cruz Biotechnology
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GITR Double Nickase Plasmid (h2) - sc-404899-NIC-2 from Santa Cruz Biotechnology
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GITR CRISPR Activation Plasmid (h) - sc-404899-ACT from Santa Cruz Biotechnology
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GITR CRISPR Activation Plasmid (h2) - sc-404899-ACT-2 from Santa Cruz Biotechnology
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GITR Lentiviral Activation Particles (h) - sc-404899-LAC from Santa Cruz Biotechnology
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GITR Lentiviral Activation Particles (h2) - sc-404899-LAC-2 from Santa Cruz Biotechnology
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GITR siRNA (h) - sc-43806 from Santa Cruz Biotechnology
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GITR shRNA Plasmid (h) - sc-43806-SH from Santa Cruz Biotechnology
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GITR shRNA (h) Lentiviral Particles - sc-43806-V from Santa Cruz Biotechnology
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GITR/TNFRSF18 RNAi - H00008784-R01V from Novus Biologicals
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GITR/TNFRSF18 RNAi - H00008784-R05 from Novus Biologicals
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GITR/TNFRSF18 RNAi - H00008784-R04 from Novus Biologicals
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GITR/TNFRSF18 RNAi - H00008784-R06 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN21749 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21749 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR02622 from Sigma-Aldrich
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TNFRSF18 siRNA (Human) - CRH5785 from Cohesion Biosciences
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TNFRSF18 - MBS8201617 from MyBioSource
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shRNA set against Human TNFRSF18 (NM_004195.2) - SHH431956 from Creative biogene
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shRNA set against Human TNFRSF18(NM_148901.1) - SHL084350 from Creative biogene
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shRNA set against Human TNFRSF18(NM_004195.2) - SHL084826 from Creative biogene
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shRNA set against Human TNFRSF18(NM_148902.1) - SHL084844 from Creative biogene
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shRNA set against Human TNFRSF18(NM_148901.1) - SHL084880 from Creative biogene
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