ALYREF

Gene Symbol ALYREF
Entrez Gene 10189
Alt Symbol ALY, ALY/REF, BEF, REF, THOC4
Species Human
Gene Type protein-coding
Description Aly/REF export factor
Other Description THO complex 4|THO complex subunit 4|ally of AML-1 and LEF-1|bZIP enhancing factor|bZIP-enhancing factor BEF|tho4|transcriptional coactivator Aly/REF
Swissprots O43672 Q86V81
Accessions EAW89699 Q86V81 AF047002 AAD09608 AF086513 BC052302 AAH52302 BU624466 EU831428 ACE87115 EU831521 ACE86440 XR_933919 NM_005782 NP_005773
Function Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX
Subcellular Location Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and DDX39B in the nucleus and nuclear speckles. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur.
Top Pathways Spliceosome, RNA transport, mRNA surveillance pathway, Herpes simplex infection

Human Aly protein fragment - ab153055 from Abcam

Category Protein
Prices $402.00
Sizes 10 µg
Source Wheat germ
Species Human
ab153055 on a 12.5% SDS-PAGE stained with Coomassie Blue.

ALY / THOC4 Antibody Blocking Peptide - LS-E4149 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

ALY / THOC4 Antibody Blocking Peptide - LS-E15846 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

Recombinant Human Aly Protein - H00010189-Q01 from Novus Biologicals

Category Protein
Prices $369.00, $529.00
Sizes 10 µg, 25 µg
Source Wheat Germ
Species Human

THOC4-Antibody-Center-Blocking-Peptide - BP16403c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

THOC4 Blocking Peptide - 33R-3282 from Fitzgerald

Category Peptide
Prices $130.00
Sizes 100 µg

THOC4 / ALY - H00010189-Q01-10 from Acris Antibodies

Category Protein
Prices $380.00
Sizes 10 µg
Species Human

THOC4 / ALY - H00010189-Q01-25 from Acris Antibodies

Category Protein
Prices $500.00
Sizes 25 µg
Species Human

ALY fusion protein - Ag10044 from Proteintech Group

Category Protein
Prices $199.00
Sizes 50 μg
Source E. coli -derived, PET28a
Species Human

Recombinant Human ALYREF, His-tagged - ALYREF-9606H from Creative Biomart

Category Protein
Source E.coli
Species Human

ALY (K161) Peptide - BS9250P from Bioworld Technology

Category Peptide
Prices $158.00
Sizes 100 µl

Recombinant Human THO complex subunit 4(ALYREF) - CSB-YP774811HU CSB-EP774811HU CSB-BP774811HU CSB-MP774811HU from Cusabio

Category Protein
Source Yeast or E.coli or Baculovirus or Mammalian cell
Species Human

THO complex subunit 4 (ALYREF), Recombinant Protein - MBS1473029 from MyBioSource

Category Protein
Prices $1,005.00, $1,005.00, $1,235.00, $1,235.00, $1,545.00, $1,545.00, $2,010.00, $2,010.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Human

THO complex subunit 4 (ALYREF), Recombinant Protein - MBS1259270 from MyBioSource

Category Protein
Prices $1,005.00, $1,005.00, $1,235.00, $1,235.00, $1,540.00, $1,540.00, $2,005.00, $2,005.00
Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell)
Source E Coli or Yeast or Baculovirus or Mammalian Cell

Aly Recombinant Protein Antigen - NBP1-90179PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human

ALYREF Peptide, Human - M34GP00542H from Creative Peptides

Category Peptide
Source Synthetic.
Species Human

Aly Recombinant Protein Antigen - NBP2-56154PEP from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 µl
Source E.coli
Species Human
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