| Gene Symbol |
ALYREF
|
| Entrez Gene |
10189
|
| Alt Symbol |
ALY, ALY/REF, BEF, REF, THOC4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Aly/REF export factor
|
| Other Description |
THO complex 4|THO complex subunit 4|ally of AML-1 and LEF-1|bZIP enhancing factor|bZIP-enhancing factor BEF|tho4|transcriptional coactivator Aly/REF
|
| Swissprots |
O43672 Q86V81
|
| Accessions |
EAW89699 Q86V81 AF047002 AAD09608 AF086513 BC052302 AAH52302 BU624466 EU831428 ACE87115 EU831521 ACE86440 XR_933919 NM_005782 NP_005773
|
| Function |
Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX
|
| Subcellular Location |
Nucleus. Nucleus speckle. Cytoplasm. Note=Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and DDX39B in the nucleus and nuclear speckles. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur.
|
| Top Pathways |
Spliceosome, RNA transport, mRNA surveillance pathway, Herpes simplex infection
|