| Gene Symbol |
KLK6
|
| Entrez Gene |
5653
|
| Alt Symbol |
Bssp, Klk7, PRSS18, PRSS9, SP59, hK6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kallikrein-related peptidase 6
|
| Other Description |
kallikrein-6|neurosin|protease M|serine protease 18|serine protease 9|zyme
|
| Swissprots |
Q92876 A6NJA1 Q6H301 A8MW09
|
| Accessions |
AAD51475 AAG33359 CAY39328 EAW71953 EAW71954 EAW71955 EAW71956 EAW71957 Q92876 AF013988 AAB66483 AK314897 BAG37411 AY279383 AY318867 AAP82446 AY318868 AY318869 AAP82448 AY318870 AY457039 AAR23148 BC015525 AAH15525 BM763657 BT006852 AAP35498 D78203 BAA11306 DQ223012 ABB04464 DQ893548 ABM84474 DQ893845 ABM84771 U62801 AAB07113 NM_001012964 NP_001012982 NM_001012965 NP_001012983 NM_002774 NP_002765 NM_001012966
|
| Function |
Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. {ECO:0000269|PubMed:11983703, ECO:0000269|PubMed:12878203, ECO:0000269|PubMed:12928483, ECO:0000269|PubMed:15557757, ECO:0000269|PubMed:16321973, ECO:0000269|PubMed:16987227}.
|
| Subcellular Location |
Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
|
| Tissue Specificity |
In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors. {ECO:0000269|PubMed:10997858, ECO:0000269|PubMed:11018688, ECO:0000269|PubMed:11668196, ECO:0000269|PubMed:12928483, ECO:0000269|PubMed:16800739}.
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