KLK6

Gene Symbol KLK6
Entrez Gene 5653
Alt Symbol Bssp, Klk7, PRSS18, PRSS9, SP59, hK6
Species Human
Gene Type protein-coding
Description kallikrein-related peptidase 6
Other Description kallikrein-6|neurosin|protease M|serine protease 18|serine protease 9|zyme
Swissprots Q92876 A6NJA1 Q6H301 A8MW09
Accessions AAD51475 AAG33359 CAY39328 EAW71953 EAW71954 EAW71955 EAW71956 EAW71957 Q92876 AF013988 AAB66483 AK314897 BAG37411 AY279383 AY318867 AAP82446 AY318868 AY318869 AAP82448 AY318870 AY457039 AAR23148 BC015525 AAH15525 BM763657 BT006852 AAP35498 D78203 BAA11306 DQ223012 ABB04464 DQ893548 ABM84474 DQ893845 ABM84771 U62801 AAB07113 NM_001012964 NP_001012982 NM_001012965 NP_001012983 NM_002774 NP_002765 NM_001012966
Function Serine protease which exhibits a preference for Arg over Lys in the substrate P1 position and for Ser or Pro in the P2 position. Shows activity against amyloid precursor protein, myelin basic protein, gelatin, casein and extracellular matrix proteins such as fibronectin, laminin, vitronectin and collagen. Degrades alpha-synuclein and prevents its polymerization, indicating that it may be involved in the pathogenesis of Parkinson disease and other synucleinopathies. May be involved in regulation of axon outgrowth following spinal cord injury. Tumor cells treated with a neutralizing KLK6 antibody migrate less than control cells, suggesting a role in invasion and metastasis. {ECO:0000269|PubMed:11983703, ECO:0000269|PubMed:12878203, ECO:0000269|PubMed:12928483, ECO:0000269|PubMed:15557757, ECO:0000269|PubMed:16321973, ECO:0000269|PubMed:16987227}.
Subcellular Location Secreted. Nucleus, nucleolus. Cytoplasm. Mitochondrion. Microsome. Note=In brain, detected in the nucleus of glial cells and in the nucleus and cytoplasm of neurons. Detected in the mitochondrial and microsomal fractions of HEK-293 cells and released into the cytoplasm following cell stress.
Tissue Specificity In fluids, highest levels found in milk of lactating women followed by cerebrospinal fluid, nipple aspirate fluid and breast cyst fluid. Also found in serum, seminal plasma and some amniotic fluids and breast tumor cytosolic extracts. Not detected in urine. At the tissue level, highest concentrations found in glandular tissues such as salivary glands followed by lung, colon, fallopian tube, placenta, breast, pituitary and kidney. Not detected in skin, spleen, bone, thyroid, heart, ureter, liver, muscle, endometrium, testis, pancreas, seminal vesicle, ovary, adrenals and prostate. In brain, detected in gray matter neurons (at protein level). Colocalizes with pathological inclusions such as Lewy bodies and glial cytoplasmic inclusions. Overexpressed in primary breast tumors but not expressed in metastatic tumors. {ECO:0000269|PubMed:10997858, ECO:0000269|PubMed:11018688, ECO:0000269|PubMed:11668196, ECO:0000269|PubMed:12928483, ECO:0000269|PubMed:16800739}.

KLK6 Human ELISA Kit - ab193706 from Abcam

Category ELISA Kit
Prices $475.00
Sizes 1 x 96 tests
Sensitivity 0.6 ng/ml
Range 0.6 ng/ml - 150 ng/ml
Data provided for demonstration purposes only. A new standard curve must be generated for each assay performed.

Human KLK6 / Kallikrein 6 ELISA Kit (Sandwich ELISA) - LS-F2697 from LifeSpan Bioscience

Category ELISA Kit
Prices $530.00
Sizes 1 plate
Sensitivity 3 pg/ml
Range 78-5000 pg/ml

Human KLK6 / Kallikrein 6 ELISA Kit - LS-F4527 from LifeSpan Bioscience

Category ELISA Kit
Prices $650.00
Sizes 1 plate
Sensitivity 0.126 ng/ml
Range 0.313 - 20 ng/ml

Rat KLK6 / Kallikrein 6 ELISA Kit (Sandwich ELISA) - LS-F7602 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity 0.064 ng/ml
Range 78-5000 pg/ml

Mouse KLK6 / Kallikrein 6 ELISA Kit (Sandwich ELISA) - LS-F9446 from LifeSpan Bioscience

Category ELISA Kit
Prices $670.00
Sizes 1 plate
Sensitivity 0.65 pg/ml
Range 78-5000 pg/ml

Human KLK6 / Kallikrein 6 ELISA Kit (Competitive EIA) - LS-F9835 from LifeSpan Bioscience

Category ELISA Kit
Prices $650.00
Sizes 1 plate
Sensitivity 44.9 pg/ml
Range 78-5000 pg/ml

Human KLK6 / Kallikrein-6 ELISA Kit - RAB0704 from Sigma-Aldrich

Category ELISA Kit
Prices $637.00
Sizes 1 kt

Kallikrein 6, KLK 6, Human, ELISA Kit - CSB-E09248h from ARP American Research Products

Category ELISA Kit
Prices $550.00, $790.00, $791.00, $794.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t
Sensitivity 0.31 ng/ml
Range 1.25 ng/ml-80 ng/ml

Human KLK6 ELISA - ELH-KLK6 from RayBiotech

Category ELISA Kit
Prices $462.00, $832.00, $1,850.00
Sizes 1 plate kit, 2 plate kit, 5 plate kit
Sensitivity 0.6 ng/ml
Range 0.6 ng/ml - 150 ng/ml
Human Kallikrein 6 ELISA Standard Curve

Kallikrein-6, ELISA Kit - MBS177174 from MyBioSource

Category ELISA Kit
Prices $425.00
Sizes 1x96 wells
Sensitivity < 3pg/ml
Range 78pg/ml-5,000pg/ml

kallikrein-related peptidase 6, ELISA Kit - MBS703076 from MyBioSource

Category ELISA Kit
Prices $250.00, $550.00, $795.00, $2,890.00, $5,465.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.31 ng/ml
Range 1.25 ng/ml-80 ng/ml

Kallikrein 6, ELISA Kit - MBS740355 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.1 ng/mL

Kallikrein 6, ELISA Kit - MBS742921 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 6, ELISA Kit - MBS043277 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 6, ELISA Kit - MBS824593 from MyBioSource

Category ELISA Kit
Prices $470.00
Sizes 96 tests
Sensitivity 3 pg/ml
Range 78 pg/ml - 5000 pg/ml

Kallikrein 6, ELISA Kit - MBS029210 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 6, ELISA Kit - MBS025627 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 6, ELISA Kit - MBS733728 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 6, ELISA Kit - MBS036897 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 6, ELISA Kit - MBS735012 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 6, ELISA Kit - MBS021801 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 6, ELISA Kit - MBS720202 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 6, ELISA Kit - MBS004948 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 6, ELISA Kit - MBS034905 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Kallikrein 6, ELISA Kit - MBS065632 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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