KCNH1
| Gene Symbol | KCNH1 |
|---|---|
| Entrez Gene | 3756 |
| Alt Symbol | EAG, EAG1, Kv10.1, TMBTS, h-eag |
| Species | Human |
| Gene Type | protein-coding |
| Description | potassium channel, voltage gated eag related subfamily H, member 1 |
| Other Description | EAG channel 1|ether-a-go-go potassium channel 1|ether-a-go-go, Drosophila, homolog of|hEAG1|potassium voltage-gated channel subfamily H member 1|potassium voltage-gated channel, subfamily H (eag-related), member 1|voltage-gated potassium channel subunit Kv10.1 |
| Swissprots | O76035 Q14CL3 O95259 B1AQ26 |
| Accessions | CCQ43886 EAW93424 EAW93425 O95259 AF078741 AAC68668 AF078742 AAC68669 AJ001366 CAA04700 AK127526 BC113709 AAI13710 BC143599 AAI43600 XM_011509514 XP_011507816 NM_002238 NP_002229 NM_172362 NP_758872 |
| Function | Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:22732247). Channel properties may be modulated by subunit assembly, but not by cyclic nucleotides (By similarity). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). {ECO:0000250|UniProtKB:Q60603, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:23881642, ECO:0000269|PubMed:9738473}. |
| Subcellular Location | Cell membrane {ECO:0000269|PubMed:21559285, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:22841712}; Multi- pass membrane protein {ECO:0000269|PubMed:21559285}. Nucleus inner membrane {ECO:0000269|PubMed:21559285}; Multi-pass membrane protein {ECO:0000269|PubMed:21559285}. Early endosome membrane {ECO:0000269|PubMed:22841712}. Note=Perinuclear KCNH1 is located to NPC-free islands. |
| Tissue Specificity | Highly expressed in brain and in myoblasts at the onset of fusion, but not in other tissues. Detected in HeLa (cervical carcinoma), SH-SY5Y (neuroblastoma) and MCF-7 (epithelial tumor) cells, but not in normal epithelial cells. |
KCNH1 CRISPR/Cas9 KO Plasmid (h) - sc-405756 from Santa Cruz Biotechnology
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KCNH1 HDR Plasmid (h) - sc-405756-HDR from Santa Cruz Biotechnology
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KCNH1 Double Nickase Plasmid (h) - sc-405756-NIC from Santa Cruz Biotechnology
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KCNH1 Double Nickase Plasmid (h2) - sc-405756-NIC-2 from Santa Cruz Biotechnology
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KCNH1 CRISPR Activation Plasmid (h) - sc-405756-ACT from Santa Cruz Biotechnology
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KCNH1 CRISPR Activation Plasmid (h2) - sc-405756-ACT-2 from Santa Cruz Biotechnology
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KCNH1 Lentiviral Activation Particles (h) - sc-405756-LAC from Santa Cruz Biotechnology
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KCNH1 Lentiviral Activation Particles (h2) - sc-405756-LAC-2 from Santa Cruz Biotechnology
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KCNH1 siRNA (h) - sc-78963 from Santa Cruz Biotechnology
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KCNH1 shRNA Plasmid (h) - sc-78963-SH from Santa Cruz Biotechnology
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KCNH1 shRNA (h) Lentiviral Particles - sc-78963-V from Santa Cruz Biotechnology
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KCNH1 RNAi - H00003756-R06 from Novus Biologicals
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KCNH1 RNAi - H00003756-R05 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN10942 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10942 from Sigma-Aldrich
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KCNH1 siRNA (Human) - CRH2532 from Cohesion Biosciences
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KCNH1 CRISPR/Cas9 KO Plasmid (h2) - sc-405756-KO-2 from Santa Cruz Biotechnology
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KCNH1 HDR Plasmid (h2) - sc-405756-HDR-2 from Santa Cruz Biotechnology
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KCNH1, siRNA - MBS8202821 from MyBioSource
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shRNA set against Human KCNH1 (NM_002238.3) - SHH323035 from Creative biogene
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KCNH1 shRNA Plasmid (Human) - CHH2532 from Cohesion Biosciences
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KCNH1 miRNA 3'UTR clone - MiUTR4H-TG04684 from Creative biogene
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