APH1A

Gene Symbol	APH1A
Entrez Gene	51107
Alt Symbol	6530402N02Rik, APH-1, APH-1A, CGI-78
Species	Human
Gene Type	protein-coding
Description	APH1A gamma secretase subunit
Other Description	anterior pharynx defective 1 homolog A|aph-1alpha|gamma-secretase subunit APH-1A|presenilin-stabilization factor
Swissprots	Q9Y386 Q9BVG0 B4DQK0 Q96BI3 Q5TB23 Q969R6 Q5TB22
Accessions	CAF86638 CAI22811 CAI22812 CAI22813 EAW53565 EAW53566 EAW53567 Q96BI3 AF151835 AAD34072 AF508787 AAN63816 AK027879 BAG51389 AK075295 BAC11529 AK075452 BAG52142 AK125685 AK297680 BAG60040 AK298832 BAG60962 AK298876 BAG60993 AK300640 BAG62329 AK307358 AK314490 AX775955 CAE11677 AX775957 CAE11678 AY113698 AAM61955 AY113699 AAM61956 AY358951 AAQ89310 BC001230 AAH01230 BC008732 AAH08732 BC009501 AAH09501 BC015568 AAH15568 BC017699 AAH17699 BC020590 AAH20590 BC068606 BI760743 DA589586 DC365601 HQ447145 ADQ31632 JF432669 ADZ15886 JF432870 ADZ16087 XM_006711362 XP_006711425 NM_001077628 NP_001071096 NM_001243771 NP_001230700 NM_001243772 NP_001230701 NM_016022 NP_057106 NR_045033 NR_045034 NR_045035
Function	Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. {ECO:0000269|PubMed:12297508, ECO:0000269|PubMed:12522139, ECO:0000269|PubMed:12763021}.
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus, Golgi stack membrane; Multi- pass membrane protein. Note=Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
Tissue Specificity	Widely expressed. Expressed in leukocytes, lung, placenta, small intestine, liver, kidney, spleen thymus, skeletal muscle, heart and brain. Isoform 1 and isoform 2 are nearly expressed at the same level. {ECO:0000269|PubMed:12110170}.
Top Pathways	Notch signaling pathway, Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human APH1a peptide - ab12394 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

APH1A / APH-1 Antibody Blocking Peptide - LS-E6421 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APH1A / APH-1 Antibody Blocking Peptide - LS-E30295 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

APH1A / APH-1 Antibody Blocking Peptide - LS-E30296 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

APH1A / APH-1 Antibody Blocking Peptide - LS-E8194 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APH1A / APH-1 Antibody Blocking Peptide - LS-E26373 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APH1A Blocking Peptide - NBP1-77272PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

APH1A Blocking Peptide - NBP1-76401PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

APH1A Peptide - P1925 from Novus Biologicals Category Peptide Species Human

APH1A-Antibody-N-term-Blocking-Peptide - BP19161a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APH1-Antibody-N-term-Blocking-Peptide - BP6302a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APH1 Peptide - GTX85061-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

APH1 Peptide - GTX85062-PEP from GeneTex Category Peptide Prices $149.00 Sizes 50 μg Species Human

APH1A blocking peptide - GTX89025-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

APH1A Peptide - AC21-1208-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

APH1A Control Peptide - AP30066CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

APH1A Control Peptide - AP30067CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

APH1 Peptide - 4003P from ProSci Category Peptide Species Human

APH1 Peptide - 4001P from ProSci Category Peptide Species Human

APH1A Peptide - 45-262P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

APH1A fusion protein - Ag2238 from Proteintech Group Category Protein Source E. coli -derived, PGEX-4T Species Human

APH1A, Peptide - MBS426550 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

APH1-Antibody-C-term-Blocking-Peptide - BP6302b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

APH1A Peptide, Human - M34GP00753H from Creative Peptides Category Peptide Source Synthetic. Species Human

Gamma-secretase subunit APH-1A (APH1A), Recombinant Protein - MBS7007797 from MyBioSource Category Protein Prices $1,080.00, $2,065.00, $3,275.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

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