RPA1

Gene Symbol	RPA1
Entrez Gene	6117
Alt Symbol	HSSB, MST075, REPA1, RF-A, RP-A, RPA70
Species	Human
Gene Type	protein-coding
Description	replication protein A1, 70kDa
Other Description	MSTP075|RF-A protein 1|RP-A p70|replication factor A protein 1|replication protein A 70 kDa DNA-binding subunit|single-stranded DNA-binding protein
Swissprots	Q59ES9 A8K0Y9 P27694
Accessions	AAS94324 EAW90574 P27694 AB209732 BAD92969 AF167994 AAQ13598 AK289704 BAF82393 BC018126 AAH18126 HQ258560 ADR83314 M63488 AAA36584 NM_002945 NP_002936
Function	As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Play
Subcellular Location	Nucleus {ECO:0000269|PubMed:17959650}. Nucleus, PML body {ECO:0000269|PubMed:17959650}. Note=Enriched in PML bodies in cells displaying alternative lengthening of their telomeres. {ECO:0000269|PubMed:17959650}.
Top Pathways	DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

RPA70 / RPA1 Antibody Blocking Peptide - LS-E3262 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RPA70 / RPA1 Antibody Blocking Peptide - LS-E20538 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RPA70 / RPA1 Antibody Blocking Peptide - LS-E20539 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RPA1-Antibody-C-term-Blocking-Peptide - BP14415b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human RPA1 protein - orb244501 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

RPA70 Peptide - AC21-2975-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

RPA1 - H00006117-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

RPA1 - H00006117-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

RPA1 fusion protein - Ag3067 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant E. coli SSB Protein - BP002628-CF76 from Syd Labs Category Protein Prices $180.00, $528.00, $2,880.00 Sizes 10 µg, 50 µg, 1 mg Source E. coli-derived. Species Escherichia coli

Recombinant Human SSB Protein - BP002628-PRO-327 from Syd Labs Category Protein Prices $160.00, $3,500.00 Sizes 20 µg, 1 mg Source Sf9 insect cells-derived. Species Human

Recombinant Human RPA1, His-tagged - RPA1-31145TH from Creative Biomart Category Protein Source E. coli

Recombinant Human RPA1, MYC/DDK-tagged - RPA1-31146H from Creative Biomart Category Protein Source HEK293 Cells

Recombinant Human RPA1, GST-tagged - RPA1-31147H from Creative Biomart Category Protein Source E. coli

Recombinant Human RPA1, GST-tagged - RPA1-2366H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Replication Protein A1 (RPA1) - RPH217Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Replication Protein A1 (RPA1) - RPH217Ra01 from Uscn Life Science Inc. Category Protein Source E.coli Species Rat

RPA1 Blocking Peptide - CBP3007 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Replication Protein A1 (RPA1) - RPH217Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Replication protein A 70 kDa DNA-binding subunit(RPA1) - CSB-YP020088HU CSB-BP020088HU CSB-MP020088HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant human Replication protein A 70 kDa DNA-binding subunit - CSB-EP020088HU from Cusabio Category Protein Source E.coli Species Human

RPA1 - TP302066 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

RPA, p70, Peptide - MBS659431 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg Species Human, Rodent

RPA, p70, Peptide - MBS659436 from MyBioSource Category Peptide Prices $290.00 Sizes 1 mg Species Human, Rodent

RPA1/RPA70, Peptide - MBS428100 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human

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