RPA1

Gene Symbol RPA1
Entrez Gene 6117
Alt Symbol HSSB, MST075, REPA1, RF-A, RP-A, RPA70
Species Human
Gene Type protein-coding
Description replication protein A1, 70kDa
Other Description MSTP075|RF-A protein 1|RP-A p70|replication factor A protein 1|replication protein A 70 kDa DNA-binding subunit|single-stranded DNA-binding protein
Swissprots Q59ES9 A8K0Y9 P27694
Accessions AAS94324 EAW90574 P27694 AB209732 BAD92969 AF167994 AAQ13598 AK289704 BAF82393 BC018126 AAH18126 HQ258560 ADR83314 M63488 AAA36584 NM_002945 NP_002936
Function As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Play
Subcellular Location Nucleus {ECO:0000269|PubMed:17959650}. Nucleus, PML body {ECO:0000269|PubMed:17959650}. Note=Enriched in PML bodies in cells displaying alternative lengthening of their telomeres. {ECO:0000269|PubMed:17959650}.
Top Pathways DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway

Rat RPA70 / RPA1 ELISA Kit (Sandwich ELISA) - LS-F8935 from LifeSpan Bioscience

Category ELISA Kit
Prices $780.00
Sizes 1 plate
Sensitivity 0.128 ng/ml
Range 0.313-20 ng/ml

Human RPA70 / RPA1 ELISA Kit (Sandwich ELISA) - LS-F8938 from LifeSpan Bioscience

Category ELISA Kit
Prices $720.00
Sizes 1 plate
Sensitivity 0.106 ng/ml
Range 0.313-20 ng/ml

Rabbit anti-RPA70 Antibody, Affinity Purified - PLA0069 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunohistochemistry</B><BR/>Rabbit Anti-RPA70 Antibody, Affinity Purified: <B>Cat. No. PLA0069</B>: Detection of Human and Mouse RPA70 by Immunohistochemistry. Sample: FFPE sections of Human stomach carcinoma (left) and Mouse CT26 colon carcinoma (right). Antibody: Affinity purified Rabbit Anti-RPA70 (<B>Cat. No. PLA0069</B>) used at a dilution of 1:1,000 (1 μg/mL). Detection: DAB

Replication Protein A1 (RPA1), Human, ELISA Kit - SEH217Hu from ARP American Research Products

Category ELISA Kit
Prices $720.00
Sizes 96 t
Sensitivity 0.106ng/mL
Range 0.312-20ng/mL

replication protein A, RPA-70, Human, ELISA Kit - E-EL-H1282 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

replication protein A, RPA-70, Rabbit, ELISA Kit - E-EL-RB0847 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

replication protein A, RPA-70, Chicken, ELISA Kit - E-EL-Ch2189 from ARP American Research Products

Category ELISA Kit
Prices $522.00
Sizes 96 t

replication protein A, RPA-70, Porcine, ELISA Kit - E-EL-P2110 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

replication protein A, RPA-70, Monkey, ELISA Kit - E-EL-MK1437 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

RPA1 (Human) IP-WB Antibody Pair - H00006117-PW1 from Acris Antibodies

Category Antibody Pair
Prices $610.00
Sizes 1 set

Human RPA-70(Replication protein A) ELISA Kit - E-EL-H1282 from Elabscience

Category ELISA Kit
Sensitivity 0.10 ng/mL
Range 0.16—10 ng/mL

Replication protein A 70 kDa DNA binding subunit (RPA1), ELISA Kit - MBS7202471 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

replication protein A 70 kDa DNA-binding subunit, ELISA Kit - MBS925374 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.078 ng/ml
Range 0.312 ng/ml-20 ng/ml

Replication protein A 70 kDa DNA-binding subunit (RPA1), ELISA Kit - MBS7244547 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Replication protein A 70 kDa DNA-binding subunit (RPA1), ELISA Kit - MBS7214663 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Replication protein A 70 kDa DNA-binding subunit (RPA1), ELISA Kit - MBS7240527 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Replication protein A 70 kDa DNA-binding subunit (RPA1), ELISA Kit - MBS7251052 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Replication protein A 70 kDa DNA-binding subunit (RPA1), ELISA Kit - MBS7215470 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Replication protein A 70 kDa DNA-binding subunit (RPA1), ELISA Kit - MBS7241098 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Replication protein A 70 kDa DNA-binding subunit (RPA1), ELISA Kit - MBS7209362 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Replication protein A 70 kDa DNA-binding subunit (RPA1), ELISA Kit - MBS7206346 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Replication protein A 70 kDa DNA-binding subunit (RPA1), ELISA Kit - MBS7214560 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Replication protein A 70 kDa DNA-binding subunit (RPA1), ELISA Kit - MBS7250674 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ELISA Kit for Replication Protein A1 (RPA1) - SEH217Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.106ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

ELISA Kit for Replication Protein A1 (RPA1) - SEH217Ra from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.128ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL
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