| Gene Symbol | RPA1 |
|---|---|
| Entrez Gene | 6117 |
| Alt Symbol | HSSB, MST075, REPA1, RF-A, RP-A, RPA70 |
| Species | Human |
| Gene Type | protein-coding |
| Description | replication protein A1, 70kDa |
| Other Description | MSTP075|RF-A protein 1|RP-A p70|replication factor A protein 1|replication protein A 70 kDa DNA-binding subunit|single-stranded DNA-binding protein |
| Swissprots | Q59ES9 A8K0Y9 P27694 |
| Accessions | AAS94324 EAW90574 P27694 AB209732 BAD92969 AF167994 AAQ13598 AK289704 BAF82393 BC018126 AAH18126 HQ258560 ADR83314 M63488 AAA36584 NM_002945 NP_002936 |
| Function | As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage (PubMed:9430682). In the cellular response to DNA damage, the RPA complex controls DNA repair and DNA damage checkpoint activation. Through recruitment of ATRIP activates the ATR kinase a master regulator of the DNA damage response (PubMed:24332808). It is required for the recruitment of the DNA double-strand break repair factors RAD51 and RAD52 to chromatin in response to DNA damage (PubMed:17765923). Also recruits to sites of DNA damage proteins like XPA and XPG that are involved in nucleotide excision repair and is required for this mechanism of DNA repair (PubMed:7697716). Play |
| Subcellular Location | Nucleus {ECO:0000269|PubMed:17959650}. Nucleus, PML body {ECO:0000269|PubMed:17959650}. Note=Enriched in PML bodies in cells displaying alternative lengthening of their telomeres. {ECO:0000269|PubMed:17959650}. |
| Top Pathways | DNA replication, Mismatch repair, Homologous recombination, Nucleotide excision repair, Fanconi anemia pathway |