| Gene Symbol |
PSD4
|
| Entrez Gene |
23550
|
| Alt Symbol |
EFA6B, TIC
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
pleckstrin and Sec7 domain containing 4
|
| Other Description |
ADP-ribosylation factor guanine nucleotide-exchange factor 6|PH and SEC7 domain-containing protein 4|SEC7 homolog|exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B|exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B|exchange factor for ARF6 B|pleckstrin homology and SEC7 domain-containing protein 4|telomeric of interleukin-1 cluster protein
|
| Swissprots |
A8K1Y0 A6NEG7 Q8NDX1 Q6GPH8 Q8IYP4 Q4ZG34 O95621
|
| Accessions |
AAX88879 ABD96831 EAW73626 EAW73627 EAW73628 Q8NDX1 AA429250 AB208798 BAD92035 AJ459781 CAD30842 AK023421 BAG51189 AK093556 AK094598 AK290045 BAF82734 AK294268 BAG57560 BC035307 AAH35307 BC073151 AAH73151 BM930990 BQ061445 BU947428 EU176621 ABW03422 U63127 AAD00107 XM_005263634 XP_005263691 XM_006712392 XP_006712455 XM_006712393 XP_006712456 XM_006712394 XP_006712457 XM_011510888 XP_011509190 XM_011510889 XP_011509191 NM_012455 NP_036587
|
| Function |
Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:12082148}. Note=Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures. Recruited to membranes via phosphatidylinositol phosphate-binding.
|
| Tissue Specificity |
Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood. {ECO:0000269|PubMed:12082148}.
|
| Top Pathways |
Endocytosis
|