PSD4

Gene Symbol PSD4
Entrez Gene 23550
Alt Symbol EFA6B, TIC
Species Human
Gene Type protein-coding
Description pleckstrin and Sec7 domain containing 4
Other Description ADP-ribosylation factor guanine nucleotide-exchange factor 6|PH and SEC7 domain-containing protein 4|SEC7 homolog|exchange factor for ADP-ribosylation factor guanine nucleotide factor 6 B|exchange factor for ADP-ribosylation factor guanine nucleotide factor 6B|exchange factor for ARF6 B|pleckstrin homology and SEC7 domain-containing protein 4|telomeric of interleukin-1 cluster protein
Swissprots A8K1Y0 A6NEG7 Q8NDX1 Q6GPH8 Q8IYP4 Q4ZG34 O95621
Accessions AAX88879 ABD96831 EAW73626 EAW73627 EAW73628 Q8NDX1 AA429250 AB208798 BAD92035 AJ459781 CAD30842 AK023421 BAG51189 AK093556 AK094598 AK290045 BAF82734 AK294268 BAG57560 BC035307 AAH35307 BC073151 AAH73151 BM930990 BQ061445 BU947428 EU176621 ABW03422 U63127 AAD00107 XM_005263634 XP_005263691 XM_006712392 XP_006712455 XM_006712393 XP_006712456 XM_006712394 XP_006712457 XM_011510888 XP_011509190 XM_011510889 XP_011509191 NM_012455 NP_036587
Function Guanine nucleotide exchange factor for ARF6 and ARL14/ARF7. Through ARL14 activation, controls the movement of MHC class II-containing vesicles along the actin cytoskeleton in dendritic cells. Involved in membrane recycling. Interacts with several phosphatidylinositol phosphate species, including phosphatidylinositol 3,4-bisphosphate, phosphatidylinositol 3,5- bisphosphate and phosphatidylinositol 4,5-bisphosphate. {ECO:0000269|PubMed:12082148, ECO:0000269|PubMed:21458045}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:12082148}. Note=Accumulates in dynamic actin-rich membrane ruffles and microvilli-like structures. Recruited to membranes via phosphatidylinositol phosphate-binding.
Tissue Specificity Widely expressed. Highest levels of expression are found in placenta, pancreas, spleen, thymus and peripheral blood. {ECO:0000269|PubMed:12082148}.
Top Pathways Endocytosis

PSD4 (P-13) - sc-161174 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-PSD4 antibody - ab154008 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-PSD4 antibody (ab154008) at 1/1000 dilution + A431 whole cell lysate at 30 µg

Anti-PSD4 antibody - ab122225 from Abcam

Prices $443.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ab122225, at a 1/100 dilution, staining PSD4 in paraffin embedded Human spleen tissue by Immunohistochemistry.

Anti-PSD4 Antibody (C-Terminus) - LS-C98002 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma; HC = hepatocarcinoma.

PSD4 Antibody - NBP2-19976 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: PSD4 Antibody [NBP2-19976] - Sample (30 ug of whole cell lysate) A: A431 7. 5% SDS PAGE gel, diluted at 1:1000.

PSD4 Antibody - NBP2-38217 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

PSD4 Antibody - NBP1-84006 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry: PSD4 Antibody [NBP1-84006] - Staining of human spleen shows strong cytoplasmic positivity in cells of white pulp.

ANTI-PSMD4 (C-TERM) antibody produced in rabbit - SAB1303544 from Sigma-Aldrich

Prices $326.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PSD4 antibody produced in rabbit - HPA034722 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PSD4: <B>Cat. No. HPA034722</B>: Immunohistochemical staining of human spleen shows strong cytoplasmic positivity in cells of white pulp.

Anti-PSD4 antibody produced in rabbit - SAB2700678 from Sigma-Aldrich

Prices $326.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PSD4: <B>Cat. No. SAB2700678</B>: Immunohistochemical analysis of paraffin-embedded Breast carcinoma, using PSD4 antibody at 1:250 dilution.

PSD4 antibody - PAB1741 from Acris Antibodies

Prices $420.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human cancer tissue reacted with PSMD4 polyclonal antibody ( Cat # PAB1741 ) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated. BC = breast carcinoma.

PSD4 - MBS272808 from MyBioSource

Prices $360.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Sample (30 ug of whole cell lysate) A: A431 7.5% SDS PAGE diluted at 1:1000

Anti-PSD4 (aa 534-762) polyclonal antibody - DPABH-04068 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

Anti-PSD4 (aa 241-330) polyclonal antibody - DPABH-20519 from Creative Diagnostics

Host Rabbit
Clonality Polyclonal

PSD4 Polyclonal Antibody - PA5-31837 from Thermo Fisher Scientific

Prices $349.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of PSD4 in paraffin-embedded breast carcinoma using a PSD4 polyclonal antibody (Product # PA5-31837) at a dilution of 1:250.

PSD4 antibody [C1C2], Internal - GTX121282 from GeneTex

Prices $119.00
Sizes 25 μl
Host Rabbit
Clonality Polyclonal
Anti-PSD4 antibody [C1C2], Internal used in IHC (Formalin-fixed paraffin-embedded sections). GTX121282

PSD4 Antibody,FITC conjugated - CSB-PA843332LC01HU from Cusabio

Host Rabbit
Clonality Polyclonal

PSD4 Antibody - CSB-PA843332LA01HU from Cusabio

Host Rabbit
Clonality Polyclonal

PSD4 Antibody,HRP conjugated - CSB-PA843332LB01HU from Cusabio

Host Rabbit
Clonality Polyclonal

PSD4 Antibody,Biotin conjugated - CSB-PA843332LD01HU from Cusabio

Host Rabbit
Clonality Polyclonal

Anti-PSD4 antibody produced in rabbit - HPA034723 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-PSD4: <B>Cat. No. HPA034723</B>: Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in non-germinal center cells.

PSD4 antibody - orb356243 from Biorbyt

Prices $289.00, $434.00
Sizes 50 μg, 100 μg
Host Rabbit
Clonality Polyclonal

EFA6B antibody - orb234045 from Biorbyt

Prices $570.00
Sizes 100 μl
Host Rabbit
Clonality Polyclonal

PSD4 Antibody - DF10161 from Affinity Biosciences

Prices $220.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

PSD4 Antibody - 44552 from Signalway Antibody

Prices $189.00, $279.00
Sizes 50 µl, 100 µl
Host Rabbit
Clonality Polyclonal
Western blot analysis PSD4 using HT-29 whole cell lysates
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