Casp8

Gene Symbol	Casp8
Entrez Gene	12370
Alt Symbol	CASP-8, FLICE, MACH, Mch5
Species	Mouse
Gene Type	protein-coding
Description	caspase 8
Other Description	Fas-linked ICE-like protease|caspase-8
Swissprots	O89110 O35669
Accessions	AAC40132 AAW80309 EDL00099 EDL00100 O89110 AF067834 AAC40131 AJ000641 CAA04196 AJ007749 CAA07677 AK146758 BAE27412 AK153340 BAE31918 AK156135 AK168812 BAE40639 AK185575 AK189229 BC006737 AAH06737 BC049955 AAH49955 BY203369 CT010166 CAJ18374 XM_006495634 XP_006495697 NM_001080126 NP_001073595 NM_001277926 NP_001264855 NM_009812 NP_033942
Function	Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.
Subcellular Location	Cytoplasm.
Tissue Specificity	Expressed in a wide variety of tissues. Highest expression in spleen, thymus, lung, liver and kidney. Lower expression in heart, brain, testis and skeletal muscle.
Top Pathways	Chagas disease (American trypanosomiasis), Viral carcinogenesis, TNF signaling pathway, Legionellosis, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Caspase-8 Protein - NBP1-99206 from Novus Biologicals Category Protein Species Mouse

Caspase-8 Protein - NBP1-99588 from Novus Biologicals Category Protein Prices $429.00 Sizes 100 tests Species Mouse

Caspase 8 (active) recombinant protein - GTX65332 from GeneTex Category Protein Prices $319.00 Sizes 100 unit Source E. coli Species Mouse

Caspase-8 (Active) recombinant protein - GTX65333 from GeneTex Category Protein Prices $199.00 Sizes 25 unit Source E. coli Species Mouse

Caspase 8 protein - orb197744 from Biorbyt Category Protein Prices $298.00 Sizes 200 μl Species Mouse

Mouse Casp-8 (HEK293 Lysate) - orb197726 from Biorbyt Category Protein Prices $255.00 Sizes 200 μg Species Mouse

Caspase 8 protein - 30R-2328 from Fitzgerald Category Protein Prices $225.00, $365.00 Sizes 25 units, 100 units Source E.coli Species Mouse

Mouse Caspase 8 Protein - abx065778 from Abbexa Category Protein Source E.coli Species Mouse

Mouse Caspase 8 Protein - abx065774 from Abbexa Category Protein Source E.coli Species Mouse

Caspase-8 / FLICE - P4487 from Acris Antibodies Category Protein Prices $430.00 Sizes 25 u Species Mouse

Recombinant mouse Casp-8 (HEK293 Lysate) - 230-10019 from RayBiotech Category Protein Source Human Embryonic Kidney 293 (HEK293) Cells Species Mouse

Recombinant mouse Casp-8 (HEK293 Supernatant) - 230-20009 from RayBiotech Category Protein Source Human Embryonic Kidney 293 (HEK293) Cells Species Mouse

Caspase 8 (CASP8), Mouse - 20-7243 from ARP American Research Products Category Protein Prices $569.00 Sizes 50 µg Source E.coli Species Mouse

Recombinant Mouse Caspase 8 - Casp8-1645M from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Caspase 8 (CASP8) - RPA853Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Caspase 8 (CASP8) - RPA853Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse Caspase-8(Casp8) - CSB-YP004553MO CSB-EP004553MO CSB-BP004553MO CSB-MP004553MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Caspase-8, mouse recombinant - 1188-100 from Biovision Category Protein Prices $285.00 Sizes 100 units Source E. coli Species Mouse

Caspase-8, mouse recombinant - 1188-25 from Biovision Category Protein Prices $145.00 Sizes 25 units Source E. coli Species Mouse

Caspase 8 (CASP8) - RPU140683 from Biomatik Category Protein Prices $275.00, $550.00, $825.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Caspase 8 (CASP8) - RPU140686 from Biomatik Category Protein Prices $275.00, $550.00, $825.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Caspase 8, Recombinant Protein - MBS2031553 from MyBioSource Category Protein Prices $200.00, $440.00, $690.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Caspase 8 (CASP8), Recombinant Protein - MBS2010714 from MyBioSource Category Protein Prices $200.00, $440.00, $690.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Caspase-8, Recombinant Protein - MBS844173 from MyBioSource Category Protein Prices $210.00, $355.00 Sizes 25 units, 100 units Source E Coli

Caspase-8 (Casp8), Recombinant Protein - MBS1072418 from MyBioSource Category Protein Prices $900.00, $900.00, $1,125.00, $1,125.00, $1,330.00, $1,330.00, $1,785.00, $1,785.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

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