Casp8

Gene Symbol	Casp8
Entrez Gene	12370
Alt Symbol	CASP-8, FLICE, MACH, Mch5
Species	Mouse
Gene Type	protein-coding
Description	caspase 8
Other Description	Fas-linked ICE-like protease|caspase-8
Swissprots	O89110 O35669
Accessions	AAC40132 AAW80309 EDL00099 EDL00100 O89110 AF067834 AAC40131 AJ000641 CAA04196 AJ007749 CAA07677 AK146758 BAE27412 AK153340 BAE31918 AK156135 AK168812 BAE40639 AK185575 AK189229 BC006737 AAH06737 BC049955 AAH49955 BY203369 CT010166 CAJ18374 XM_006495634 XP_006495697 NM_001080126 NP_001073595 NM_001277926 NP_001264855 NM_009812 NP_033942
Function	Most upstream protease of the activation cascade of caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A induced cell death. Binding to the adapter molecule FADD recruits it to either receptor. The resulting aggregate called death- inducing signaling complex (DISC) performs CASP8 proteolytic activation. The active dimeric enzyme is then liberated from the DISC and free to activate downstream apoptotic proteases. Proteolytic fragments of the N-terminal propeptide (termed CAP3, CAP5 and CAP6) are likely retained in the DISC. Cleaves and activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May participate in the GZMB apoptotic pathways. Cleaves ADPRT. Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC. Likely target for the cowpox virus CRMA death inhibitory protein.
Subcellular Location	Cytoplasm.
Tissue Specificity	Expressed in a wide variety of tissues. Highest expression in spleen, thymus, lung, liver and kidney. Lower expression in heart, brain, testis and skeletal muscle.
Top Pathways	Chagas disease (American trypanosomiasis), Viral carcinogenesis, TNF signaling pathway, Legionellosis, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Caspase 8 (CASP8), Mouse, ELISA Kit - SEA853Mu from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Sensitivity 0.069ng/mL Range 0.156-10ng/mL

Caspase-8 (CASP8), Mouse, ELISA Kit - CSB-EL004553MO from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Caspase-8, Casp8, Mouse, ELISA Kit - E2015m from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.156-10 ng/mL

Caspase-8, Mouse, ELISA Kit - E03C0095 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 0.5-10ng/ml

Mouse Caspase-8 ELISA Kit - MC0102 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Mouse CASP8(Caspase 8) ELISA Kit - E-EL-M0063 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Mouse CASP8 (Caspase 8) CLIA Kit - E-CL-M0056 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

Caspase 8, ELISA Kit - MBS059413 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

caspase 8, apoptosis-related cysteine peptidase, ELISA Kit - MBS915464 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity The minimum detectable dose of mouse CASP8 is typically less than 11.7 pg/ml.The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations. Range 46.88 pg/ml -3000 pg/ml.

caspase 8, apoptosis-related cysteine peptidase, ELISA Kit - MBS9310812 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Mouse Caspase-8(CASP8) ELISA kit - CSB-EL004553MO from Cusabio Category ELISA Kit Sensitivity 11.7pg/ml Range 46.88 pg/ml-3000 pg/ml

Mouse Caspase-8 ELISA - E03C0095 from BlueGene Biotech Category ELISA Kit

ELISA Kit for Caspase 8 (CASP8) - SEA853Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.069ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

Mouse Caspase 8 (CASP8) ELISA Kit - EKU02999 from Biomatik Category ELISA Kit Prices $605.00, $2,691.00, $4,899.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 0.117 ng/mL Range 0.312-20 ng/mL

Mouse CASP8(Caspase 8) ELISA Kit - E-EL-M0063 from Iwai North America Inc. Category ELISA Kit Prices $580.00 Sizes 1 kit Sensitivity 0.1 ng/mL Range 0.16~10 ng/mL

Mouse CASP8 (Caspase 8) CLIA Kit - E-CL-M0056 from Iwai North America Inc. Category CLIA Kit Prices $722.50 Sizes 1 kit Sensitivity 0.094ng/mL Range 0.156-10ng/mL

Mouse Caspase 8 ELISA Kit - abx153772 from Abbexa Category ELISA Kit Sensitivity 0.069 ng/ml Range 0.156 ng/ml - 10 ng/ml

Mouse Caspase-8 ELISA Kit - abx255059 from Abbexa Category ELISA Kit Range 0.156 ng/ml - 10 ng/ml

Caspase 8 (CASP8), Mouse, ELISA Kit - DL-CASP8-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.156-10 ng/mL

Mouse CASP8 ELISA Kit - abx570109 from Abbexa Category ELISA Kit Sensitivity 0.069 ng/ml Range 0.156 ng/ml - 10 ng/ml

Mouse Caspase-8 (CASP8) ELISA Kit - EKC36487 from Biomatik Category ELISA Kit Prices $705.00, $2,820.00, $5,288.00 Sizes 96 t, 5x96t, 10x96t Sensitivity 11.7 pg/ml Range 46.88 pg/ml-3000 pg/ml

Mouse Caspase-8 ELISA Kit - EKE54081 from Biomatik Category ELISA Kit Prices $685.40, $2,912.95, $5,483.20 Sizes 96 t, 5x96t, 10x96t Range 0.156-10 ng/mL

Casp8 - EKM1422 from Nordic BioSite Sensitivity 0.094ng/ml Range 0.156-10ng/ml

Mouse Casp8 ELISA Kit - E047238 from Biobool Category ELISA Kit Sensitivity 0.094ng/mL

Mouse caspase-8 ELISA Kit - E047328 from Biobool Category ELISA Kit

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