IKBKB

Gene Symbol	IKBKB
Entrez Gene	3551
Alt Symbol	IKK-beta, IKK2, IKKB, IMD15, NFKBIKB
Species	Human
Gene Type	protein-coding
Description	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Other Description	I-kappa-B kinase 2|I-kappa-B-kinase beta|IKK-B|inhibitor of nuclear factor kappa-B kinase subunit beta|nuclear factor NF-kappa-B inhibitor kinase beta
Swissprots	O14920 O75327 B4E0U4 B4DZ30
Accessions	AAT65965 EAW63222 EAW63223 EAW63224 EAW63225 EAW63226 O14920 AB209090 BAD92327 AF029684 AAC51860 AF031416 AAC64675 AF080158 AAD08997 AI379342 AK091090 AK091297 BAG52329 AK093537 AK095687 AK097828 AK290952 BAF83641 AK298241 BAG60507 AK302723 BAG63942 AK303294 BAG64369 AK303528 BAG64556 AK316418 BAH14789 AL708460 BC006231 AAH06231 BC090865 BC108694 AAI08695 BC127663 AAI27664 BC141978 AAI41979 BC144080 BX648165 DA043516 DA105584 DA159382 DA709000 XM_005273490 XP_005273547 XM_005273491 XP_005273548 XM_005273492 XP_005273549 XM_005273493 XP_005273550 XM_005273494 XP_005273551 XM_005273495 XP_005273552 XM_005273496 XP_005273553 XM_005273498 XP_005273555 XM_011544517 XP_011542819 XM_011544518 XP_011542820 XM_011544519 XP_011542821 XM_011544520 XP_011542822 XM_011544521 XP_011542823 XM_011544522 XP_011542824 XR_949402 NM_001190720 NP_001177649 NM_001242778 NP_001229707 NM_001556 NP_001547 NR_033818 NR_033819 NR_040009 NM_001190721 NM_001190722
Function	Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since t
Subcellular Location	Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
Tissue Specificity	Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
Top Pathways	HTLV-I infection, Osteoclast differentiation, RIG-I-like receptor signaling pathway, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence® IKKβ siRNA I - 6377 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence® IKKβ siRNA II - 6378 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

IKKβ siRNA (h) - sc-35644 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IKKβ shRNA Plasmid (h) - sc-35644-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

IKKβ shRNA (h) Lentiviral Particles - sc-35644-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MISSION® esiRNA - EHU007771 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® siRNA - SIHK0951 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0952 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

MISSION® siRNA - SIHK0953 from Sigma-Aldrich Category siRNA Prices $25.00 Sizes 0.25 nmol

CompoZr® Knockout ZFN Kit - CKOZFN1027 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1027 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09322 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09322

IKBKB siRNA (Human) - CRH2370 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IKK beta RNAi - H00003551-R03 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

IKBKB - MBS8217369 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human IKBKB (NM_001556.2) - SHH318001 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human IKBKB(NM_001190720.2) - SHL169678 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human IKBKB(NM_001556.2) - SHL169694 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human IKBKB(NM_001242778.1) - SHL169794 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human IKBKB(NM_001190720.2) - SHL169812 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human IKBKB(NM_001556.2) - SHL169814 from Creative biogene Category siRNA Species Reactivities Human

Human IKBKB siRNA - orb262872 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

IKBKB shRNA Plasmid (Human) - CHH2370 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

IKBKB miRNA 3'UTR clone - MiUTR1H-04856 from Creative biogene Species Reactivities Human

IKBKB miRNA 3'UTR clone - MiUTR1H-04857 from Creative biogene Species Reactivities Human

Search more