IKBKB

Gene Symbol IKBKB
Entrez Gene 3551
Alt Symbol IKK-beta, IKK2, IKKB, IMD15, NFKBIKB
Species Human
Gene Type protein-coding
Description inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta
Other Description I-kappa-B kinase 2|I-kappa-B-kinase beta|IKK-B|inhibitor of nuclear factor kappa-B kinase subunit beta|nuclear factor NF-kappa-B inhibitor kinase beta
Swissprots O14920 O75327 B4E0U4 B4DZ30
Accessions AAT65965 EAW63222 EAW63223 EAW63224 EAW63225 EAW63226 O14920 AB209090 BAD92327 AF029684 AAC51860 AF031416 AAC64675 AF080158 AAD08997 AI379342 AK091090 AK091297 BAG52329 AK093537 AK095687 AK097828 AK290952 BAF83641 AK298241 BAG60507 AK302723 BAG63942 AK303294 BAG64369 AK303528 BAG64556 AK316418 BAH14789 AL708460 BC006231 AAH06231 BC090865 BC108694 AAI08695 BC127663 AAI27664 BC141978 AAI41979 BC144080 BX648165 DA043516 DA105584 DA159382 DA709000 XM_005273490 XP_005273547 XM_005273491 XP_005273548 XM_005273492 XP_005273549 XM_005273493 XP_005273550 XM_005273494 XP_005273551 XM_005273495 XP_005273552 XM_005273496 XP_005273553 XM_005273498 XP_005273555 XM_011544517 XP_011542819 XM_011544518 XP_011542820 XM_011544519 XP_011542821 XM_011544520 XP_011542822 XM_011544521 XP_011542823 XM_011544522 XP_011542824 XR_949402 NM_001190720 NP_001177649 NM_001242778 NP_001229707 NM_001556 NP_001547 NR_033818 NR_033819 NR_040009 NM_001190721 NM_001190722
Function Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since t
Subcellular Location Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts.
Tissue Specificity Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood.
Top Pathways HTLV-I infection, Osteoclast differentiation, RIG-I-like receptor signaling pathway, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer

IKKβ (L570) Antibody - 2678 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from THP-1 and A20 cells using IKKβ (L570) Antibody.

IKKβ (D30C6) Rabbit mAb - 8943 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone D30C6
Western blot analysis of extracts from various cell lines using IKKβ (D30C6) Rabbit mAb.

IKKβ (2C8) Rabbit mAb - 2370 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone 2C8
Western blot analysis of extracts from HeLa, NIH/3T3 and PC-12 cells using IKKβ (2C8) Rabbit mAb.

IKKβ Antibody - 2684 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from HeLa, NIH/3T3 and PC12 cells, using IKKbeta Antibody.

IKKα/β (H-470) - sc-7607 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
IKKα/β (H-470): sc-7607. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing cytoplasmic staining.

IKKβ (C-20) - sc-7329 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IKKβ (C-20): sc-7329. Immunoperoxidase staining of formalin-fixed, paraffin-embedded human breast tumor showing cytoplasmic staining.

IKKβ (H-4) - sc-8014 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
IKKβ (H-4) sc-8014. Immunoperoxidase staining of formalin fixed, paraffin-embedded human parathyroid gland tissue showing cytoplasmic staining of glandular cells. Kindly provided by The Swedish Human Protein Atlas (HPA) program.

IKKβ (P-20) - sc-34673 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IKKβ (P-20): sc-34673. Immunoperoxidase staining of formalin fixed, paraffin-embedded human lung tissue showing cytoplasmic and nuclear staining of respiratory epithelial cells.

IKKβ (T-20) - sc-7330 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IKKβ (T-20): sc-7330. Western blot analysis of IKKβ expression in Jurkat (A), HL-60 (B) and HeLa (C) whole cell lysates.

IKKβ (S-13) - sc-34674 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
IKKβ (S-13): sc-34674. Immunoperoxidase staining of formalin fixed, paraffin-embedded human rectum tissue showing cytoplasmic staining of glandular cells.

IKKβ (62AT216) - sc-130152 from Santa Cruz Biotechnology

Prices $279.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IKKb (62AT216): sc-130152. Western blot analysis of IKKb expression in Jurkat whole cell lysate.

IKKβ (24) - sc-135948 from Santa Cruz Biotechnology

Prices $279.00
Sizes 50 µg/500 µl
Host Mouse
Clonality Monoclonal
IKKβ (24): sc-135948. Western blot analysis of IKKβ expression in HeLa whole cell lysate.

IKKβ (10A9B6) - sc-56918 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
IKKβ (10A9B6): sc-56918. Western blot analysis of IKKβ expression in Jurkat (A), A-673 (B), HeLa (C), BJAB (D), K-562 (E) and Daudi (F) whole cell lysates.

p-IKK α/β (Ser 176) - sc-21661 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
p-IKKα/β (Ser 176)-R: sc-21661-R. Western blot analysis of IKKα/β phosphorylation in untreated (A), TNFα treated (B) and TNFα and lambda protein phosphatase treated (C) HeLa whole cell lysates.

p-IKKα/β (Ser 180/Ser 181)-R - sc-23470-R from Santa Cruz Biotechnology

Prices $61.00
Sizes 100 µg/0.5 ml
Host Rabbit
Clonality Polyclonal

p-IKKα/β (Thr 23) - sc-21660 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-IKK beta (phospho Y188) antibody - ab53694 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
ab53694 at 1/50 dilution staining IKK beta in human breast carcinoma by Immunohistochemistry, Paraffin embedded tissue, in the absence or presence of the immunising peptide.

Anti-IKK beta (phospho Y188) antibody - ab194519 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IKK beta (phospho Y188) antibody (ab194519) at 1/500 dilutionLane 1 : COS7 cell extractLane 2 : COS7 cell extract with antigen-specific peptide

Anti-IKK beta (phospho Y188) antibody - ab195785 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IKK beta (phospho Y188) antibody (ab195785) at 1/500 dilutionLane 1 : COS7 whole cell lysate with antigen-specific peptideLane 2 : COS7 whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-IKK beta (phospho Y199) antibody - ab59195 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded human breast carcinoma tissue using ab59195 at 1/50 dilution. Left image: untreated. Right image: sample treated with immunising peptide.

Anti-IKK beta (phospho Y199) antibody - ab195923 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-IKK beta (phospho Y199) antibody (ab195923) at 1/500 dilutionLane 1 : TNF alpha treated HeLa whole cell lysate with antigen-specific peptideLane 2 : TNF alpha treated HeLa whole cell lysateLysates/proteins at 12.5 µg per lane.

Anti-IKK beta (phospho Y199) antibody - ab194845 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunofluorescent analysis of methanol-fixed HeLa cells labeling IKK beta (phospho Y199) with ab194845 at 1/100 dilution.

Anti-IKK beta antibody - ab55404 from Abcam

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using ab55404 (1/50 dilution), in the presence or absence of the immunizing peptide.

Anti-IKK beta antibody - ab6146 from Abcam

Prices $384.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-IKK beta antibody (ab6146) at 1/500 dilution + Jurkat whole cell lysateObserved band size : 87 kDa (why is the actual band size different from the predicted?)

Anti-IKK beta antibody - ab7611 from Abcam

Prices $373.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
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