Gene Symbol | IKBKB |
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Entrez Gene | 3551 |
Alt Symbol | IKK-beta, IKK2, IKKB, IMD15, NFKBIKB |
Species | Human |
Gene Type | protein-coding |
Description | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta |
Other Description | I-kappa-B kinase 2|I-kappa-B-kinase beta|IKK-B|inhibitor of nuclear factor kappa-B kinase subunit beta|nuclear factor NF-kappa-B inhibitor kinase beta |
Swissprots | O14920 O75327 B4E0U4 B4DZ30 |
Accessions | AAT65965 EAW63222 EAW63223 EAW63224 EAW63225 EAW63226 O14920 AB209090 BAD92327 AF029684 AAC51860 AF031416 AAC64675 AF080158 AAD08997 AI379342 AK091090 AK091297 BAG52329 AK093537 AK095687 AK097828 AK290952 BAF83641 AK298241 BAG60507 AK302723 BAG63942 AK303294 BAG64369 AK303528 BAG64556 AK316418 BAH14789 AL708460 BC006231 AAH06231 BC090865 BC108694 AAI08695 BC127663 AAI27664 BC141978 AAI41979 BC144080 BX648165 DA043516 DA105584 DA159382 DA709000 XM_005273490 XP_005273547 XM_005273491 XP_005273548 XM_005273492 XP_005273549 XM_005273493 XP_005273550 XM_005273494 XP_005273551 XM_005273495 XP_005273552 XM_005273496 XP_005273553 XM_005273498 XP_005273555 XM_011544517 XP_011542819 XM_011544518 XP_011542820 XM_011544519 XP_011542821 XM_011544520 XP_011542822 XM_011544521 XP_011542823 XM_011544522 XP_011542824 XR_949402 NM_001190720 NP_001177649 NM_001242778 NP_001229707 NM_001556 NP_001547 NR_033818 NR_033819 NR_040009 NM_001190721 NM_001190722 |
Function | Serine kinase that plays an essential role in the NF- kappa-B signaling pathway which is activated by multiple stimuli such as inflammatory cytokines, bacterial or viral products, DNA damages or other cellular stresses. Acts as part of the canonical IKK complex in the conventional pathway of NF-kappa-B activation and phosphorylates inhibitors of NF-kappa-B on 2 critical serine residues. These modifications allow polyubiquitination of the inhibitors and subsequent degradation by the proteasome. In turn, free NF-kappa-B is translocated into the nucleus and activates the transcription of hundreds of genes involved in immune response, growth control, or protection against apoptosis. In addition to the NF-kappa-B inhibitors, phosphorylates several other components of the signaling pathway including NEMO/IKBKG, NF-kappa-B subunits RELA and NFKB1, as well as IKK-related kinases TBK1 and IKBKE. IKK-related kinase phosphorylations may prevent the overproduction of inflammatory mediators since t |
Subcellular Location | Cytoplasm. Nucleus. Membrane raft. Note=Colocalized with DPP4 in membrane rafts. |
Tissue Specificity | Highly expressed in heart, placenta, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, testis and peripheral blood. |
Top Pathways | HTLV-I infection, Osteoclast differentiation, RIG-I-like receptor signaling pathway, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer |
IKKβ (L570) Antibody - 2678 from Cell Signaling Technology
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IKKβ (D30C6) Rabbit mAb - 8943 from Cell Signaling Technology
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IKKβ (2C8) Rabbit mAb - 2370 from Cell Signaling Technology
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IKKβ Antibody - 2684 from Cell Signaling Technology
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IKKα/β (H-470) - sc-7607 from Santa Cruz Biotechnology
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IKKβ (C-20) - sc-7329 from Santa Cruz Biotechnology
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IKKβ (H-4) - sc-8014 from Santa Cruz Biotechnology
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IKKβ (P-20) - sc-34673 from Santa Cruz Biotechnology
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IKKβ (T-20) - sc-7330 from Santa Cruz Biotechnology
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IKKβ (S-13) - sc-34674 from Santa Cruz Biotechnology
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IKKβ (62AT216) - sc-130152 from Santa Cruz Biotechnology
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IKKβ (24) - sc-135948 from Santa Cruz Biotechnology
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IKKβ (10A9B6) - sc-56918 from Santa Cruz Biotechnology
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p-IKK α/β (Ser 176) - sc-21661 from Santa Cruz Biotechnology
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p-IKKα/β (Ser 180/Ser 181)-R - sc-23470-R from Santa Cruz Biotechnology
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p-IKKα/β (Thr 23) - sc-21660 from Santa Cruz Biotechnology
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Anti-IKK beta (phospho Y188) antibody - ab53694 from Abcam
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Anti-IKK beta (phospho Y188) antibody - ab194519 from Abcam
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Anti-IKK beta (phospho Y188) antibody - ab195785 from Abcam
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Anti-IKK beta (phospho Y199) antibody - ab59195 from Abcam
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Anti-IKK beta (phospho Y199) antibody - ab195923 from Abcam
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Anti-IKK beta (phospho Y199) antibody - ab194845 from Abcam
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Anti-IKK beta antibody - ab55404 from Abcam
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Anti-IKK beta antibody - ab6146 from Abcam
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Anti-IKK beta antibody - ab7611 from Abcam
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