| Gene Symbol |
APOC1
|
| Entrez Gene |
341
|
| Alt Symbol |
Apo-CI, ApoC-I
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
apolipoprotein C-I
|
| Other Description |
apo-CIB|apoC-IB|apolipoprotein C-I variant I|apolipoprotein C1
|
| Swissprots |
Q6IB97 B2R526 P02654
|
| Accessions |
AAA51763 AAA88018 AAD02506 AAQ91813 ACN81312 EAW57307 EAW57308 P02654 AF308154 AAG49499 AF308155 AAG49500 AI310334 AI885116 AK225971 AK312036 BAG34973 AM392727 CAL37605 BC009698 AAH09698 BC055093 AAH55093 BT007142 AAP35806 CR456907 CAG33188 GQ129384 ACT64518 GQ129385 ACT64519 M27359 AAA51762 X00570 CAA25235 XM_005258855 XP_005258912 NM_001645 NP_001636
|
| Function |
Inhibitor of lipoprotein binding to the low density lipoprotein (LDL) receptor, LDL receptor-related protein, and very low density lipoprotein (VLDL) receptor. Associates with high density lipoproteins (HDL) and the triacylglycerol-rich lipoproteins in the plasma and makes up about 10% of the protein of the VLDL and 2% of that of HDL. Appears to interfere directly with fatty acid uptake and is also the major plasma inhibitor of cholesteryl ester transfer protein (CETP). Binds free fatty acids and reduces their intracellular esterification. Modulates the interaction of APOE with beta-migrating VLDL and inhibits binding of beta-VLDL to the LDL receptor-related protein. {ECO:0000269|PubMed:17339654, ECO:0000303|PubMed:25160599}.
|
| Subcellular Location |
Secreted {ECO:0000303|PubMed:2835369}.
|
| Tissue Specificity |
Synthesized mainly in liver and to a minor degree in intestine. Also found in the lung and spleen. {ECO:0000269|PubMed:2835369}.
|
![Western Blot: Apolipoprotein C1 Overexpression Lysate (Native) [L018T6] - Lane 1: APOC1 transfected lysate (9 KDa). Lane 2: Non-transfected lysate.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/28375_Apolipoprotein-C1-Overexpression-Lysate-(Native)-Western-Blot-L018T6-img0001.jpg)