| Gene Symbol | SPTLC2 |
|---|---|
| Entrez Gene | 9517 |
| Alt Symbol | HSN1C, LCB2, LCB2A, NSAN1C, SPT2, hLCB2a |
| Species | Human |
| Gene Type | protein-coding |
| Description | serine palmitoyltransferase, long chain base subunit 2 |
| Other Description | LCB 2|SPT 2|long chain base biosynthesis protein 2a|serine palmitoyltransferase 2|serine palmitoyltransferase, subunit II|serine-palmitoyl-CoA transferase 2 |
| Swissprots | Q16685 O15270 |
| Accessions | AAD09621 EAW81297 EAW81298 EAW81299 O15270 AB011098 BAA25452 BC005123 AAH05123 BG024616 BM992457 BQ338973 DQ893297 ABM84223 DQ896786 ABM87785 U15555 AAC50871 W24363 Y08686 CAA69942 XM_011537384 XP_011535686 NM_004863 NP_004854 |
| Function | Serine palmitoyltransferase (SPT). The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC2-SPTSSB complex displays a preference for C18-CoA substrate. {ECO:0000269|PubMed:19416851, ECO:0000269|PubMed:20920666}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. |
| Tissue Specificity | Widely expressed. {ECO:0000269|PubMed:17023427}. |
| Top Pathways | Sphingolipid signaling pathway, Sphingolipid metabolism |