Gene Symbol | Il4 |
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Entrez Gene | 16189 |
Alt Symbol | BSF-1, Il-4 |
Species | Mouse |
Gene Type | protein-coding |
Description | interleukin 4 |
Other Description | B-cell IgG differentiation factor|B-cell growth factor 1|B-cell stimulatory factor 1|IGG1 induction factor|interleukin-4|lymphocyte stimulatory factor 1 |
Swissprots | P07750 |
Accessions | CAA28731 CAA28873 CAA28874 EDL33576 EDL33577 EDL33578 P07750 AA199406 AB174765 BAD83771 AF352783 AAK52901 AF359558 BC027514 AAH27514 BX529138 M13238 AAA39307 M25892 AAA39298 X03532 CAA27233 NM_021283 NP_067258 NR_027491 |
Function | Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. |
Subcellular Location | Secreted. |
Top Pathways | Cytokine-cytokine receptor interaction, Allograft rejection, Autoimmune thyroid disease, Intestinal immune network for IgA production, Asthma |
IL-4 CRISPR/Cas9 KO Plasmid (m) - sc-421110 from Santa Cruz Biotechnology
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IL-4 HDR Plasmid (m) - sc-421110-HDR from Santa Cruz Biotechnology
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IL-4 Double Nickase Plasmid (m) - sc-421110-NIC from Santa Cruz Biotechnology
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IL-4 Double Nickase Plasmid (m2) - sc-421110-NIC-2 from Santa Cruz Biotechnology
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IL-4 CRISPR Activation Plasmid (m) - sc-421110-ACT from Santa Cruz Biotechnology
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IL-4 CRISPR Activation Plasmid (m2) - sc-421110-ACT-2 from Santa Cruz Biotechnology
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IL-4 Lentiviral Activation Particles (m) - sc-421110-LAC from Santa Cruz Biotechnology
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IL-4 Lentiviral Activation Particles (m2) - sc-421110-LAC-2 from Santa Cruz Biotechnology
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IL-4 siRNA (m) - sc-39624 from Santa Cruz Biotechnology
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IL-4 shRNA Plasmid (m) - sc-39624-SH from Santa Cruz Biotechnology
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IL-4 shRNA (m) Lentiviral Particles - sc-39624-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN33800 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33800 from Sigma-Aldrich
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IL4 siRNA (Mouse) - CRM2063 from Cohesion Biosciences
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IL4 - MBS8233751 from MyBioSource
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shRNA set against Mouse IL4 (NM_021283.2) - SHH318985 from Creative biogene
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IL4 shRNA Plasmid (Mouse) - CHM2063 from Cohesion Biosciences
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