| Gene Symbol |
Il4
|
| Entrez Gene |
16189
|
| Alt Symbol |
BSF-1, Il-4
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
interleukin 4
|
| Other Description |
B-cell IgG differentiation factor|B-cell growth factor 1|B-cell stimulatory factor 1|IGG1 induction factor|interleukin-4|lymphocyte stimulatory factor 1
|
| Swissprots |
P07750
|
| Accessions |
CAA28731 CAA28873 CAA28874 EDL33576 EDL33577 EDL33578 P07750 AA199406 AB174765 BAD83771 AF352783 AAK52901 AF359558 BC027514 AAH27514 BX529138 M13238 AAA39307 M25892 AAA39298 X03532 CAA27233 NM_021283 NP_067258 NR_027491
|
| Function |
Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes.
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Allograft rejection, Autoimmune thyroid disease, Intestinal immune network for IgA production, Asthma
|