MMP2

Gene Symbol MMP2
Entrez Gene 4313
Alt Symbol CLG4, CLG4A, MMP-2, MMP-II, MONA, TBE-1
Species Human
Gene Type protein-coding
Description matrix metallopeptidase 2
Other Description 72 kDa type IV collagenase|collagenase type IV-A|matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)|matrix metalloproteinase-2|matrix metalloproteinase-II|neutrophil gelatinase
Swissprots E9PE45 B4DWH3 B2R6U1 P08253 Q9UCJ8
Accessions AAA52027 AAA52028 AAU10089 CAR95108 CAS92766 EAW82824 EAW82825 EAW82826 EAW82827 EAW82828 P08253 AK301536 BAG63035 AK310314 AK312711 BAG35588 AL046162 AL542407 AL832088 AU133104 AU279927 BC002576 AAH02576 BP341649 BQ004983 BX357054 CA446916 DA579926 DA739456 DA993141 DB059054 DB154582 DQ385623 ABD38929 DQ891952 ABM82878 DQ895138 ABM86064 J03210 AAA35701 X58968 NM_001127891 NP_001121363 NM_001302508 NP_001289437 NM_001302509 NP_001289438 NM_001302510 NP_001289439 NM_004530 NP_004521
Function Isoform 2: Mediates the proteolysis of CHUK/IKKA and initiates a primary innate immune response by inducing mitochondrial-nuclear stress signaling with activation of the pro- inflammatory NF-kappaB, NFAT and IRF transcriptional pathways.
Subcellular Location Isoform 1: Secreted, extracellular space, extracellular matrix. Membrane. Nucleus. Note=Colocalizes with integrin alphaV/beta3 at the membrane surface in angiogenic blood vessels and melanomas. Found in mitochondria, along microfibrils, and in nuclei of cardiomyocytes.
Tissue Specificity Produced by normal skin fibroblasts. PEX is expressed in a number of tumors including gliomas, breast and prostate. {ECO:0000269|PubMed:11751392}.
Top Pathways Leukocyte transendothelial migration, Bladder cancer, GnRH signaling pathway, Estrogen signaling pathway, Proteoglycans in cancer

Active human MMP2 full length protein - ab198429 from Abcam

Category Protein
Prices $1,250.00
Sizes 20 µg
Source HEK 293 cells
Species Human
4-20% SDS-PAGE Coomassie staining Lane 1: ab198429 (2.5µg) Lane 2: Protein Marker

Active human MMP2 full length protein - ab168864 from Abcam

Category Protein
Prices $522.00
Sizes 5 µg
Source Native
Species Human

Active human MMP2 full length protein - ab81550 from Abcam

Category Protein
Prices $239.00
Sizes 10 µg
Source E. coli
Species Human

Active human MMP2 full length protein - ab174022 from Abcam

Category Protein
Prices $357.00
Sizes 50 µg
Source HEK 293 cells
Species Human
SDS-PAGE analysis of reduced ab174022 staining overnight with Coomassie Blue. DTT-reduced Protein migrates as 66-71 kDa.

Active human MMP2 full length protein - ab157044 from Abcam

Category Protein
Prices $588.00
Sizes 10 µg
Source Baculovirus infected sf9 cells
Species Human

Active human MMP2 full length protein - ab125181 from Abcam

Category Protein
Prices $192.00
Sizes 10 µg
Source HEK 293 cells
Species Human
Detection of gelatinolytic activity of ab125181 MMP2 protein. 10 ng of ab125181 in 25 µl of 25 mM Tris-glycine buffer (pH 6.8) was mixed with 2x SDS-sample buffer (without ß-mercaptoethanol) and incubated at 37°C for 10 minutes. Samples were loaded on a 10% acrylamide-Tris-glycine gel containing 0.1% gelatin and electrophoresed using Tris-glycine (pH 8.3) with 0.1% SDS. Electrophoresis was performed at 90V for 2 hours. The gel was washed 3 times in 40-50 ml of 2.5% Triton X-100 for 15 minutes. The gel was immersed in 40-50 ml of 50 mM Tris-glycine (pH 7.5), 100 mM NaCl, 4 mM CaCl 2 and 0.02% Triton X-100 and incubated at 37°C for 16 hours. For detection of the gelatinolytic activity, the gel was stained with 0.05% Commassie Blue. ab125181 produced a prominent gelatinolytic band corresponding to a molecular mass of ~ 68 kDa. See Abreview

Human MMP2 full length protein - ab151866 from Abcam

Category Protein
Source HEK 293 cells
Species Human

Human MMP2 peptide - ab92853 from Abcam

Category Peptide

MMP2 peptide - ab41039 from Abcam

Category Peptide

MMP2 peptide - ab41040 from Abcam

Category Peptide

MMP2 peptide - ab41041 from Abcam

Category Peptide

MMP2 peptide - ab41042 from Abcam

Category Peptide

MMP2 peptide - ab44848 from Abcam

Category Peptide

MMP2 Antibody Blocking Peptide - LS-E2623 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

MMP2 Antibody Blocking Peptide - LS-E10636 from LifeSpan Bioscience

Category Peptide
Prices $145.00
Sizes 100 µg

MMP-2 Partial Recombinant Protein - H00004313-Q01 from Novus Biologicals

Category Protein
Prices $369.00
Sizes 10 µg
Species Human

Recombinant Human MMP-2 Protein - H00004313-P01 from Novus Biologicals

Category Protein
Prices $529.00
Sizes 25 µg
Source Wheat Germ
Species Human

MMP-2 Protein - NBP1-99194 from Novus Biologicals

Category Protein
Prices $279.00
Sizes 10 µg
Species Human

MMP-2 Protein - NBP1-99918 from Novus Biologicals

Category Protein
Prices $499.00
Sizes 5 µg
Species Human

MMP-2 Protein - NBP1-99603 from Novus Biologicals

Category Protein
Species Human

Collagenase Type 2 Protein - P5277 from Novus Biologicals

Category Protein
Prices $199.00
Sizes 50 mg
Species Bacteria

Collagenase Type 2 Protein - P5273 from Novus Biologicals

Category Protein
Prices $199.00
Sizes 100 mg
Species Bacteria

MMP-2 Peptide - P1818 from Novus Biologicals

Category Peptide
Species Human

MMP2-Antibody-Center-Blocking-peptide - BP13693c from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg

MMP2-Antibody-N-term-Blocking-Peptide - BP6210a from Abgent, a WuXi AppTec company

Category Peptide
Prices $80.00
Sizes 100 µg
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