| Gene Symbol | Adipoq |
|---|---|
| Entrez Gene | 11450 |
| Alt Symbol | 30kDa, APN, Acdc, Acrp30, Ad, GBP28, adipo, apM1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | adiponectin, C1Q and collagen domain containing |
| Other Description | 30 kDa adipocyte complement-related protein|adipocyte complement related protein|adipocyte complement-related 30 kDa protein|adipocyte, C1Q and collagen domain containing|adipocyte, C1q and collagen domain-containing protein|adipocyte-specific protein AdipoQ|adiponectin |
| Swissprots | Q9DC68 Q60994 Q6GTX4 Q62400 |
| Accessions | AAK13417 CBL63520 EDK97661 Q60994 AK003138 BAB22597 AK041214 BAC30866 AK134112 BAE22019 AX767955 CAE01097 AX767957 CAE01098 AY749429 AAW70555 AY754346 AAW82905 BC028770 AAH28770 U37222 AAA80543 U49915 AAB06706 NM_009605 NP_033735 |
| Function | Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. {ECO:0000269|PubMed:11479627, ECO:0000269|PubMed:11479628, ECO:0000269|PubMed:12840063, ECO:0000269|PubMed:15734737, ECO:0000269|PubMed:15760892}. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Synthesized exclusively by adipocytes and secreted into plasma. |
| Top Pathways | Adipocytokine signaling pathway, Type II diabetes mellitus, PPAR signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |
Acrp30 CRISPR/Cas9 KO Plasmid (m) - sc-418962 from Santa Cruz Biotechnology
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Acrp30 HDR Plasmid (m) - sc-418962-HDR from Santa Cruz Biotechnology
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Acrp30 Double Nickase Plasmid (m) - sc-418962-NIC from Santa Cruz Biotechnology
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Acrp30 Double Nickase Plasmid (m2) - sc-418962-NIC-2 from Santa Cruz Biotechnology
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Acrp30 CRISPR Activation Plasmid (m) - sc-418962-ACT from Santa Cruz Biotechnology
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Acrp30 CRISPR Activation Plasmid (m2) - sc-418962-ACT-2 from Santa Cruz Biotechnology
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Acrp30 Lentiviral Activation Particles (m) - sc-418962-LAC from Santa Cruz Biotechnology
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Acrp30 Lentiviral Activation Particles (m2) - sc-418962-LAC-2 from Santa Cruz Biotechnology
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Acrp30 siRNA (m) - sc-45891 from Santa Cruz Biotechnology
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Acrp30 shRNA Plasmid (m) - sc-45891-SH from Santa Cruz Biotechnology
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Acrp30 shRNA (m) Lentiviral Particles - sc-45891-V from Santa Cruz Biotechnology
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CompoZr® Knockout ZFN Kit - CKOZFN26336 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND26336 from Sigma-Aldrich
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ADIPOQ siRNA (Mouse) - CRM0035 from Cohesion Biosciences
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ADIPOQ - MBS8200182 from MyBioSource
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Acrp30 CRISPR/Cas9 KO Plasmid (m2) - sc-418962-KO-2 from Santa Cruz Biotechnology
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Acrp30 HDR Plasmid (m2) - sc-418962-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Mouse ADIPOQ (NM_009605.4) - SHH232458 from Creative biogene
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shRNA set against Mouse Adipoq(NM_009605.4) - SHG042441 from Creative biogene
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Mouse ADIPOQ siRNA - orb279511 from Biorbyt
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ADIPOQ shRNA Plasmid (Mouse) - CHM0035 from Cohesion Biosciences
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ADIPOQ miRNA 3'UTR clone - MiUTR1M-01243 from Creative biogene
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