Gene Symbol | Adipoq |
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Entrez Gene | 11450 |
Alt Symbol | 30kDa, APN, Acdc, Acrp30, Ad, GBP28, adipo, apM1 |
Species | Mouse |
Gene Type | protein-coding |
Description | adiponectin, C1Q and collagen domain containing |
Other Description | 30 kDa adipocyte complement-related protein|adipocyte complement related protein|adipocyte complement-related 30 kDa protein|adipocyte, C1Q and collagen domain containing|adipocyte, C1q and collagen domain-containing protein|adipocyte-specific protein AdipoQ|adiponectin |
Swissprots | Q9DC68 Q60994 Q6GTX4 Q62400 |
Accessions | AAK13417 CBL63520 EDK97661 Q60994 AK003138 BAB22597 AK041214 BAC30866 AK134112 BAE22019 AX767955 CAE01097 AX767957 CAE01098 AY749429 AAW70555 AY754346 AAW82905 BC028770 AAH28770 U37222 AAA80543 U49915 AAB06706 NM_009605 NP_033735 |
Function | Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW. {ECO:0000269|PubMed:11479627, ECO:0000269|PubMed:11479628, ECO:0000269|PubMed:12840063, ECO:0000269|PubMed:15734737, ECO:0000269|PubMed:15760892}. |
Subcellular Location | Secreted. |
Tissue Specificity | Synthesized exclusively by adipocytes and secreted into plasma. |
Top Pathways | Adipocytokine signaling pathway, Type II diabetes mellitus, PPAR signaling pathway, Non-alcoholic fatty liver disease (NAFLD), AMPK signaling pathway |
Recombinant Mouse Adiponectin/Acrp30 Protein - NBC1-18447 from Novus Biologicals
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Adiponectin/Acrp30 Recombinant Protein - P4528 from Novus Biologicals
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Adiponectin/Acrp30 Protein - NBP1-99296 from Novus Biologicals
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Adiponectin/Acrp30 Protein - NBP1-99385 from Novus Biologicals
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Adiponectin/Acrp30 Protein - NBP1-99666 from Novus Biologicals
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Adiponectin/Acrp30 Protein - NBP1-99683 from Novus Biologicals
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Adiponectin/Acrp30 Recombinant Protein - P4530 from Novus Biologicals
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Adiponectin/Acrp30 Recombinant Protein - P4329 from Novus Biologicals
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Adiponectin/Acrp30 Recombinant Protein - P4326 from Novus Biologicals
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Adiponectin recombinant protein - GTX65326 from GeneTex
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Adiponectin Recombinant Protein (Active) - GTX48319-PRO from GeneTex
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Adiponectin recombinant protein - GTX65325 from GeneTex
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Recombinant Mouse Adiponectin/Acrp30, CF - 5095-AC-050 from R&D Systems
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Recombinant Mouse gAdiponectin/gAcrp30, CF - 1119-AC-025 from R&D Systems
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Recombinant Mouse Adiponectin (OPCA00734) - OPCA00734 from Aviva Systems Biology
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Acrp30 Protein (OPPA00512) - OPPA00512 from Aviva Systems Biology
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gAcrp30 Protein (OPPA00691) - OPPA00691 from Aviva Systems Biology
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Acrp30 Protein (OPPA00694) - OPPA00694 from Aviva Systems Biology
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Acrp30 Protein (OPPA01516) - OPPA01516 from Aviva Systems Biology
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Mouse Acrp30 protein - orb80247 from Biorbyt
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Mouse ma protein - orb245355 from Biorbyt
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Mouse ADIPOQ His tag protein - orb83939 from Biorbyt
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Mouse Acrp30 protein - orb180167 from Biorbyt
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Adiponectin protein - 30R-2657 from Fitzgerald
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Adiponectin protein (Mouse) - 30R-3198 from Fitzgerald
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