ACVR1

Gene Symbol ACVR1
Entrez Gene 90
Alt Symbol ACTRI, ACVR1A, ACVRLK2, ALK2, FOP, SKR1, TSRI
Species Human
Gene Type protein-coding
Description activin A receptor, type I
Other Description TGF-B superfamily receptor type I|activin A receptor, type II-like kinase 2|activin receptor type I|activin receptor type-1|activin receptor-like kinase 2|hydroxyalkyl-protein kinase|serine/threonine-protein kinase receptor R1
Swissprots Q04771
Accessions AAY15094 AAY24272 ADL14509 AJF45349 CAA02405 CAZ91465 CBX47654 EAX11438 EAX11439 EAX11440 EAX11441 EAX11442 EAX11443 Q04771 AK297765 BAG60113 AK313630 BC033867 AAH33867 BC036748 DA796090 L02911 AAA36614 Z22534 CAA80256 XM_005246939 XP_005246996 XM_005246940 XP_005246997 XM_006712825 XP_006712888 XM_011512106 XP_011510408 XM_011512107 XP_011510409 XM_011512108 XP_011510410 NM_001105 NP_001096 NM_001111067 NP_001104537
Function On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis (By similarity). {ECO:0000250}.
Subcellular Location Membrane; Single-pass type I membrane protein.
Tissue Specificity Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells.
Top Pathways Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells

ACVR1-Over-expression-Lysate - LY10656a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag ACVR1 (arrow) using his tag antibody. 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the ACVR1 gene

Cynomolgus ALK-2 / ACVR1 / ALK2 HEK293 Cell Lysate (WB positive control) - 90058-C02HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Cynomolgus

Human ALK-2 / ACVR1 / ALK2 Insect Cell Lysate (WB positive control) - 10227-H08BL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Human ALK-2 / ACVR1 HEK293 Cell Lysate (WB positive control) - 10227-H03HL-300 from Sino Biological

Category Cell Lysate
Prices $195.00
Sizes 300 µg
Species Human

Cynomolgus ALK-2 / ACVR1 / ALK2 Protein (Fc Tag) - 90058-C02H-100 90058-C02H-200 from Sino Biological

Category Protein
Prices $178.00, $178.00
Sizes 100 µg, 200 µg
Species Cynomolgus

Activin RIA/ALK-2/Activin Receptor Type 1 Overexpression Lysate (Native) - NBP2-11417 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Activin Receptor Type 1 Overexpression Lysate (Adult Normal) [NBP2-11417] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Activin Receptor Type 1.

Activin RIA/ALK-2/Activin Receptor Type 1 Overexpression Lysate (Native) - NBP2-10943 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: Activin Receptor Type 1 Overexpression Lysate (Adult Normal) [NBP2-10943] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Activin Receptor Type 1.

Cynomolgus ALK-2 / ACVR1 / ALK2 Protein (Fc Tag) - 90058-C02H-100 from Sino Biological

Category Protein
Species Cynomolgus

Panoply™ Human ACVR1 Knockdown Stable Cell Line - CSC-DC000214 from Creative biogene

Category Cell Line
Species Human
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