Gene Symbol | KCNK1 |
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Entrez Gene | 3775 |
Alt Symbol | DPK, HOHO, K2P1, K2p1.1, KCNO1, TWIK-1, TWIK1 |
Species | Human |
Gene Type | protein-coding |
Description | potassium channel, two pore domain subfamily K, member 1 |
Other Description | inward rectifying potassium channel protein TWIK-1|potassium channel KCNO1|potassium channel subfamily K member 1|potassium inwardly-rectifying channel, subfamily K, member 1|tandem of P domains in a weak inward rectifying K+ channel 1 |
Swissprots | Q5T5E8 O00180 Q13307 |
Accessions | EAW69989 EAW69990 O00180 AK090902 AK314016 BAG36727 BC018051 AAH18051 BQ022191 DQ892383 ABM83309 DQ895595 ABM86521 U33632 AAB01688 U76996 AAB97878 U90065 AAB51147 XM_011544184 XP_011542486 NM_002245 NP_002236 |
Function | Weakly inward rectifying potassium channel that contributes to the regulation of the resting membrane potential. {ECO:0000269|PubMed:22282804, ECO:0000269|PubMed:8605869}. |
Subcellular Location | Cell membrane {ECO:0000269|PubMed:8605869}; Multi-pass membrane protein {ECO:0000269|PubMed:22282804}. |
Tissue Specificity | Widely expressed with high levels in heart and brain and lower levels in placenta, lung, liver and kidney (PubMed:8605869). {ECO:0000269|PubMed:8605869}. |
TWIK-1 CRISPR/Cas9 KO Plasmid (h) - sc-405238 from Santa Cruz Biotechnology
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TWIK-1 HDR Plasmid (h) - sc-405238-HDR from Santa Cruz Biotechnology
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TWIK-1 Double Nickase Plasmid (h) - sc-405238-NIC from Santa Cruz Biotechnology
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TWIK-1 Double Nickase Plasmid (h2) - sc-405238-NIC-2 from Santa Cruz Biotechnology
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TWIK-1 CRISPR Activation Plasmid (h) - sc-405238-ACT from Santa Cruz Biotechnology
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TWIK-1 CRISPR Activation Plasmid (h2) - sc-405238-ACT-2 from Santa Cruz Biotechnology
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TWIK-1 Lentiviral Activation Particles (h) - sc-405238-LAC from Santa Cruz Biotechnology
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TWIK-1 Lentiviral Activation Particles (h2) - sc-405238-LAC-2 from Santa Cruz Biotechnology
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TWIK-1 siRNA (h) - sc-42349 from Santa Cruz Biotechnology
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TWIK-1 shRNA Plasmid (h) - sc-42349-SH from Santa Cruz Biotechnology
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TWIK-1 shRNA (h) Lentiviral Particles - sc-42349-V from Santa Cruz Biotechnology
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KCNK1 RNAi - H00003775-R01 from Novus Biologicals
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MISSION® esiRNA - EHU048241 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN10962 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND10962 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR06241 from Sigma-Aldrich
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KCNK1 siRNA (Human) - CRH2549 from Cohesion Biosciences
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shRNA set against Human KCNK1 (NM_002245.3) - SHH323359 from Creative biogene
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KCNK1 shRNA Plasmid (Human) - CHH2549 from Cohesion Biosciences
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KCNK1 miRNA 3'UTR clone - MiUTR3H-04376 from Creative biogene
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