CXCL12

Gene Symbol	CXCL12
Entrez Gene	493806
Alt Symbol	SDF-1
Species	Cat
Gene Type	protein-coding
Description	chemokine (C-X-C motif) ligand 12
Other Description	C-X-C motif chemokine 12|stromal cell-derived factor 1
Swissprots	O62657 Q54AJ3
Accessions	O62657 AB011965 BAA28601 AB011966 BAA28602 XM_006937984 XP_006938046 NM_001009847 NP_001009847
Function	Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation (By simila
Subcellular Location	Secreted.
Top Pathways	Cytokine-cytokine receptor interaction, Leukocyte transendothelial migration, Intestinal immune network for IgA production, Chemokine signaling pathway, Rheumatoid arthritis

• Antibodies
• Proteins/Peptides

CXCL12/SDF-1 Recombinant Protein - P4854 from Novus Biologicals Category Protein Prices $549.00 Sizes 10 µg Species Cat

CXCL12/SDF-1 Protein - NBP1-99333 from Novus Biologicals Category Protein Prices $309.00 Sizes 10 µg Species Cat

CXCL12/SDF-1 Protein - NBP1-99642 from Novus Biologicals Category Protein Species Cat

Recombinant Human/Feline CXCL12/SDF-1 beta (aa 19-93) - 2716-SD-025 from R&D Systems Category Protein Source E. coli-derived, Ser19-Met93

Recombinant Human/Feline CXCL12/SDF-1 beta (aa 19-93), CF - 2716-SD-025/CF from R&D Systems Category Protein Source E. coli-derived, Ser19-Met93

SDF 1b Feline Protein (OPPA02236) - OPPA02236 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli Species Cat

SDF1 beta protein - 30R-2598 from Fitzgerald Category Protein Prices $245.00 Sizes 10 µg Source E.coli Species Cat

CXCL12 / SDF1 - P4854 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg

Stromal Cell-Derived Factor-1 beta Feline Recombinant (CXCL12) - 228-10495-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Cat

Recombinant Feline SDF-1 beta / CXCL12 (aa 3-72) - 228-10495-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli. Species Human

Recombinant Feline SDF-1 beta / CXCL12 (aa 3-72) - 228-10495-3 from RayBiotech Category Protein Prices $2,880.00 Sizes 3 µg Source Escherichia Coli. Species Human

SDF 1b Feline - CHPS-254 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Cat

Feline SDF-1-beta - 600101 from ABBIOTEC Category Protein Prices $250.00 Sizes 10 µg Source E. coli. Endotoxin level as measured by LAL is <0.01ng/ug or <0.1EU/ug. Species Cat

Recombinant Feline SDF-1 Protein - BP000305-CHM-247 from Syd Labs Category Protein Prices $160.00, $2,700.00 Sizes 10 µg, 1 mg Source E. coli-derived. Species Cat

Recombinant Feline Chemokine (C-X-C Motif) Ligand 12(SDF-1b) - CXCL12-110F from Creative Biomart Category Protein Source Escherichia Coli .

SDF 1b Feline - KJB-391 from Reagent Proteins Category Protein Prices $348.00, $3,124.00 Sizes 10.00 µg, 1 mg Source E.coli Species Cat

Stromal Cell-Derived Factor-1 beta (CXCL12) - 002-001-W23-0005 from Rockland Immunochemicals Inc Prices $98.00 Sizes 5 µg Species Cat

Stromal Cell-Derived Factor-1 beta (CXCL12) - 002-001-W23-0025 from Rockland Immunochemicals Inc Prices $234.00 Sizes 25 µg Species Cat

Stromal Cell-Derived Factor-1 beta (CXCL12) - 002-001-W23-0100 from Rockland Immunochemicals Inc Prices $442.00 Sizes 100 µg Species Cat

Stromal Cell-Derived Factor-1 beta (CXCL12) - 002-001-W23-1000 from Rockland Immunochemicals Inc Prices $2,808.00 Sizes 1 mg Species Cat

Recombinant Cat Stromal cell-derived factor 1(CXCL12) - CSB-YP527681CA CSB-EP527681CA CSB-BP527681CA CSB-MP527681CA from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell

SDF-1beta/CXCL12, feline recombinant - 4389-10 from Biovision Category Protein Prices $190.00 Sizes 10 μg Source E. coli Species Cat

SDF-1beta/CXCL12, feline recombinant - 4389-50 from Biovision Category Protein Prices $475.00 Sizes 50 μg Source E. coli Species Cat

SDF-1beta/CXCL12, feline recombinant - 4389-1000 from Biovision Category Protein Prices $3,450.00 Sizes 1 mg Source E. coli Species Cat

Recombinant Human/Feline CXCL12/SDF-1 beta (aa 19-93), CF - 2716-SD/CF from R&D Systems Category Protein Prices $299.00 Sizes 25 µg Source E. coli -derived Ser19-Met93 Species Human

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