| Gene Symbol |
CXCL12
|
| Entrez Gene |
493806
|
| Alt Symbol |
SDF-1
|
| Species |
Cat
|
| Gene Type |
protein-coding
|
| Description |
chemokine (C-X-C motif) ligand 12
|
| Other Description |
C-X-C motif chemokine 12|stromal cell-derived factor 1
|
| Swissprots |
O62657 Q54AJ3
|
| Accessions |
O62657 AB011965 BAA28601 AB011966 BAA28602 XM_006937984 XP_006938046 NM_001009847 NP_001009847
|
| Function |
Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T- lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Plays a protective role after myocardial infarction. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation (By simila
|
| Subcellular Location |
Secreted.
|
| Top Pathways |
Cytokine-cytokine receptor interaction, Leukocyte transendothelial migration, Intestinal immune network for IgA production, Chemokine signaling pathway, Rheumatoid arthritis
|
