Gene Symbol | Gpaa1 |
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Entrez Gene | 14731 |
Alt Symbol | C80044, mGAA1 |
Species | Mouse |
Gene Type | protein-coding |
Description | GPI anchor attachment protein 1 |
Other Description | GAA1 protein homolog|glycosylphosphatidylinositol anchor attachment 1 protein |
Swissprots | Q3TNU9 Q9WTK3 Q9R1U8 |
Accessions | BAA82586 BAA82591 BAB03275 EDL29547 EDL29548 Q9WTK3 AB002136 BAA82589 AB006970 BAB03274 AK077518 BAC36840 AK164219 BAE37686 AK164978 BAE37988 AK168057 AK177221 AK188140 AK192435 AK200986 AK212219 BC006697 AAH06697 XM_011245457 XP_011243759 NM_010331 NP_034461 |
Function | Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate. {ECO:0000269|PubMed:10793132, ECO:0000269|PubMed:10898732}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. |
Tissue Specificity | Ubiquitously expressed in fetal and adult tissues. Expressed at higher levels in fetal tissues than adult tissues. In embryos abundant in the choroid plexus, skeletal muscle,. {ECO:0000269|PubMed:10898732}. |
Top Pathways | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis |
GPAA1 CRISPR/Cas9 KO Plasmid (m) - sc-420636 from Santa Cruz Biotechnology
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GPAA1 HDR Plasmid (m) - sc-420636-HDR from Santa Cruz Biotechnology
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GPAA1 Double Nickase Plasmid (m) - sc-420636-NIC from Santa Cruz Biotechnology
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GPAA1 Double Nickase Plasmid (m2) - sc-420636-NIC-2 from Santa Cruz Biotechnology
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GPAA1 CRISPR Activation Plasmid (m) - sc-420636-ACT from Santa Cruz Biotechnology
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GPAA1 CRISPR Activation Plasmid (m2) - sc-420636-ACT-2 from Santa Cruz Biotechnology
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GPAA1 Lentiviral Activation Particles (m) - sc-420636-LAC from Santa Cruz Biotechnology
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GPAA1 Lentiviral Activation Particles (m2) - sc-420636-LAC-2 from Santa Cruz Biotechnology
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GPAA1 siRNA (m) - sc-60716 from Santa Cruz Biotechnology
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GPAA1 shRNA Plasmid (m) - sc-60716-SH from Santa Cruz Biotechnology
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GPAA1 shRNA (m) Lentiviral Particles - sc-60716-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU054731 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN32654 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND32654 from Sigma-Aldrich
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GPAA1 siRNA (Mouse) - CRM1642 from Cohesion Biosciences
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GPAA1 - MBS8211690 from MyBioSource
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shRNA set against Mouse GPAA1 (NM_010331.2) - SHH305606 from Creative biogene
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shRNA set against Mouse Gpaa1(NM_010331.2) - SHH095375 from Creative biogene
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Mouse GPAA1 siRNA - orb281118 from Biorbyt
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GPAA1 shRNA Plasmid (Mouse) - CHM1642 from Cohesion Biosciences
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GPAA1 miRNA 3'UTR clone - MiUTR1M-05259 from Creative biogene
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