MNAT1

Gene Symbol MNAT1
Entrez Gene 4331
Alt Symbol CAP35, MAT1, RNF66, TFB3
Species Human
Gene Type protein-coding
Description MNAT CDK-activating kinase assembly factor 1
Other Description CDK-activating kinase assembly factor MAT1|CDK7/cyclin-H assembly factor|RING finger protein 66|RING finger protein MAT1|cyclin G1 interacting protein|cyclin-G1-interacting protein|menage a trois 1 (CAK assembly factor)|menage a trois homolog 1, cyclin H assembly factor
Swissprots Q15817 G3V1U8 Q6ICQ7 P51948
Accessions AAN47195 EAW80787 EAW80788 EAW80789 EAW80790 EAW80791 P51948 AA053721 AK308701 BC000820 AAH00820 BU620200 CD701743 CR450336 CAG29332 HQ447795 ADQ32279 U61835 AAB05248 X87843 CAA61112 X92669 CAA63356 XM_005267687 XP_005267744 XM_005267688 XP_005267745 XM_011536795 XP_011535097 NM_001177963 NP_001171434 NM_002431 NP_002422
Function Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. {ECO:0000269|PubMed:10024882}.
Subcellular Location Nucleus.
Tissue Specificity Highest levels in colon and testis. Moderate levels are present thymus, prostate, ovary, and small intestine. The lowest levels are found in spleen and leukocytes.
Top Pathways Nucleotide excision repair, Basal transcription factors

Mat1 CRISPR/Cas9 KO Plasmid (h) - sc-418121 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mat1 HDR Plasmid (h) - sc-418121-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mat1 Double Nickase Plasmid (h) - sc-418121-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mat1 Double Nickase Plasmid (h2) - sc-418121-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mat1 CRISPR Activation Plasmid (h) - sc-418121-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mat1 CRISPR Activation Plasmid (h2) - sc-418121-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mat1 Lentiviral Activation Particles (h) - sc-418121-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mat1 Lentiviral Activation Particles (h2) - sc-418121-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Mat1 siRNA (h) - sc-35861 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Mat1 shRNA Plasmid (h) - sc-35861-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Mat1 shRNA (h) Lentiviral Particles - sc-35861-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MNAT1 RNAi - H00004331-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU044421 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14444 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14444 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR12086 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr12086

MNAT1 siRNA (Human) - CRH2942 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MNAT1 (NM_002431.3) - SHH343196 from Creative biogene

Category siRNA
Species Reactivities Human

Human MNAT1 siRNA - orb263444 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MNAT1 shRNA Plasmid (Human) - CHH2942 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MNAT1 miRNA 3'UTR clone - MiUTR3H-05196 from Creative biogene

Species Reactivities Human
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