Gene Symbol | CHRNA1 |
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Entrez Gene | 1134 |
Alt Symbol | ACHRA, ACHRD, CHRNA, CMS2A, FCCMS, SCCMS |
Species | Human |
Gene Type | protein-coding |
Description | cholinergic receptor, nicotinic, alpha 1 (muscle) |
Other Description | acetylcholine receptor subunit alpha|acetylcholine receptor, nicotinic, alpha 1 (muscle)|cholinergic receptor, nicotinic, alpha polypeptide 1 (muscle)|muscle nicotinic acetylcholine receptor|nicotinic acetylcholine receptor alpha subunit|nicotinic cholinergic receptor alpha 1 |
Swissprots | D3DPE8 B4DRV6 P02708 |
Accessions | AAY14687 CAA26344 CAA34960 CAA49705 EAX11124 EAX11125 EAX11126 EAX11127 EAX11128 P02708 AK291338 BAF84027 AK299445 BAG61418 AK315312 BAG37716 BC006314 BC043196 BG828551 CD013889 DQ323657 ABD27888 DQ323658 ABD27889 S77094 AAD14247 Y00762 CAA68731 NM_000079 NP_000070 NM_001039523 NP_001034612 |
Function | After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. |
Subcellular Location | Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. |
Tissue Specificity | Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus. |
Top Pathways | Neuroactive ligand-receptor interaction |
Human Nicotinic Acetylcholine Receptor alpha 1 protein fragment - ab114482 from Abcam
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Nicotinic Acetylcholine Receptor alpha 1 peptide - ab189888 from Abcam
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CHRNA1 Antibody Blocking Peptide - LS-E10717 from LifeSpan Bioscience
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Recombinant Human Nicotinic Acetylcholine R alpha 1/CHRNA1 Protein - H00001134-Q01 from Novus Biologicals
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Nicotinic Acetylcholine R alpha 1/CHRNA1 Peptide - NBP1-07122PEP from Novus Biologicals
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CHRNA1-Antibody-C-term-Blocking-peptide - BP13550b from Abgent, a WuXi AppTec company
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Recombinant human Acetylcholine receptor subunit alpha (OPCA00051) - OPCA00051 from Aviva Systems Biology
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Human CHRNA1 protein - orb244109 from Biorbyt
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E.coli CHRNA1 protein - orb244112 from Biorbyt
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CHRNA1 Blocking Peptide - 33R-8867 from Fitzgerald
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CHRNA1 Blocking Peptide - 33R-1210 from Fitzgerald
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CHRNA1 Blocking Peptide - 33R-9265 from Fitzgerald
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CHRNA1 Blocking Peptide - abx062066 from Abbexa
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Acetylcholine receptor alpha subunit - H00001134-Q01-10 from Acris Antibodies
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Acetylcholine receptor alpha subunit - H00001134-Q01-25 from Acris Antibodies
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CHRNA1 fusion protein - ag0933 from Proteintech Group
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CHRNA1 fusion protein - Ag4375 from Proteintech Group
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Recombinant Human CHRNA1 - CHRNA1-30388TH from Creative Biomart
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Recombinant Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) - RPA981Hu01 from Uscn Life Science Inc.
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Recombinant Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) - RPA981Ra01 from Uscn Life Science Inc.
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CHRNA1 Blocking Peptide - CBP3172 from Cohesion Biosciences
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AChRα1 (E217) Peptide - BS2850P from Bioworld Technology
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Acetylcholine receptor protein, alpha subunit... - pep0264 from Covalab
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Recombinant Cholinergic Receptor, Nicotinic, Alpha 1 (CHRNa1) - RPA981Hu01 from Cloud-clone
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Recombinant Torpedo californica Acetylcholine receptor subunit alpha - CSB-YP005386TOT CSB-BP005386TOT CSB-MP005386TOT from Cusabio
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