| Gene Symbol | Il1r1 |
|---|---|
| Entrez Gene | 16177 |
| Alt Symbol | CD121a, CD121b, IL-1R1, IL-iR, Il1r-1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | interleukin 1 receptor, type I |
| Other Description | CD121 antigen-like family member A|IL-1 receptor alpha chain|IL-1R-1|IL-1R-alpha|IL-1RT-1|IL-1RT1|interleukin-1 receptor alpha|interleukin-1 receptor type 1|interleukin-1 receptor type I|p80 |
| Swissprots | P13504 |
| Accessions | EDL14572 P13504 AK048550 BAC33372 AK054137 BAC35666 AK166301 BC109135 AAI09136 M20658 AAA39279 XM_006495713 XP_006495776 XM_006495714 XP_006495777 XM_006495715 XP_006495778 XM_006495716 XP_006495779 XM_006495717 XP_006495780 XM_006495718 XP_006495781 XM_006495719 XP_006495782 XM_006495720 XP_006495783 XM_006495721 XP_006495784 XM_006495722 XP_006495785 XM_006495723 XP_006495786 XM_011238436 XP_011236738 NM_001123382 NP_001116854 NM_008362 NP_032388 |
| Function | Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the corecptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex (By similarity). {ECO:0000250}. |
| Subcellular Location | Membrane; Single-pass type I membrane protein. Cell membrane {ECO:0000305}. Secreted {ECO:0000250}. |
| Top Pathways | Amoebiasis, Inflammatory mediator regulation of TRP channels, HTLV-I infection, Osteoclast differentiation, Cytokine-cytokine receptor interaction |
IL-1RI CRISPR/Cas9 KO Plasmid (m) - sc-421098 from Santa Cruz Biotechnology
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IL-1RI HDR Plasmid (m) - sc-421098-HDR from Santa Cruz Biotechnology
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IL-1RI Double Nickase Plasmid (m) - sc-421098-NIC from Santa Cruz Biotechnology
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IL-1RI Double Nickase Plasmid (m2) - sc-421098-NIC-2 from Santa Cruz Biotechnology
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IL-1RI CRISPR Activation Plasmid (m) - sc-421098-ACT from Santa Cruz Biotechnology
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IL-1RI CRISPR Activation Plasmid (m2) - sc-421098-ACT-2 from Santa Cruz Biotechnology
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IL-1RI Lentiviral Activation Particles (m) - sc-421098-LAC from Santa Cruz Biotechnology
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IL-1RI Lentiviral Activation Particles (m2) - sc-421098-LAC-2 from Santa Cruz Biotechnology
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IL-1RI siRNA (m) - sc-35652 from Santa Cruz Biotechnology
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IL-1RI shRNA Plasmid (m) - sc-35652-SH from Santa Cruz Biotechnology
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IL-1RI shRNA (m) Lentiviral Particles - sc-35652-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU166251 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN33765 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND33765 from Sigma-Aldrich
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IL1R1 siRNA (Mouse) - CRM2051 from Cohesion Biosciences
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IL1R1 - MBS827738 from MyBioSource
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shRNA set against Mouse IL1R1 (NM_008362.2) - SHH318549 from Creative biogene
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shRNA set against Mouse Il1r1(NM_008362.2) - SHL172314 from Creative biogene
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shRNA set against Mouse Il1r1(NM_001123382.1) - SHL172506 from Creative biogene
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Mouse IL1R1 siRNA - orb281527 from Biorbyt
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IL1R1 shRNA Plasmid (Mouse) - CHM2051 from Cohesion Biosciences
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IL1R1 miRNA 3'UTR clone - MiUTR1M-05994 from Creative biogene
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IL1R1 miRNA 3'UTR clone - MiUTR1M-05995 from Creative biogene
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